INT24820

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.98
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
spinal 2
leukocytes 2
sciatic nerve 2
EPI 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 100.00 Very High Very High Very High
analgesia 5 99.96 Very High Very High Very High
dexamethasone 2 99.84 Very High Very High Very High
epidural 6 99.66 Very High Very High Very High
mu opioid receptor 3 99.54 Very High Very High Very High
Inflammation 10 99.42 Very High Very High Very High
Opioid 16 99.40 Very High Very High Very High
Potency 3 99.32 Very High Very High Very High
Enkephalin 7 99.28 Very High Very High Very High
Sciatic nerve 6 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 1 100.00 Very High Very High Very High
Reprotox - General 2 1 99.72 Very High Very High Very High
INFLAMMATION 8 99.42 Very High Very High Very High
Opiate Addiction 1 99.16 Very High Very High Very High
Substance Withdrawal Syndrome 3 98.20 Very High Very High Very High
Injury 6 96.84 Very High Very High Very High
Antisocial Personality Disorder 9 94.72 High High
Stress 3 93.68 High High
Disease 1 92.48 High High
Nociception 2 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that incubation of cells with MSH/isobutylmethylxanthine (IBMX) resulted in strong melanogenic and morphologic responses in high metastatic hybrids compared to parental cells and the low metastatic hybrid, and that high metastatic hybrids exhibit increased mRNA expression for MC1-R accompanied by increased 125I-alphaMSH binding.
Positive_regulation (increased) of MSH Binding (binding) of
1) Confidence 0.67 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.53 Pain Relevance 0.14
After the transplants, spinal CSF samples revealed increased concentrations of met-enkephalin in three of the five patients, and increased concentrations of catecholamines in the four patients in whom they were determined.
Positive_regulation (increased) of met-enkephalin Binding (concentrations) of in spinal
2) Confidence 0.50 Published 1993 Journal Anesthesiology Section Body Doc Link 8214743 Disease Relevance 0.06 Pain Relevance 0
Slight and transient withdrawal symptoms and mood changes were demonstrated on the second day in the whole sample of patients, in association with a significant, but moderate, elevation of heart rate, blood pressure, NE (two-fold), EPI (five-fold), ACTH (two-fold) and CORT (two-fold) plasma levels, in response to opioid receptor-antagonist administration.
Positive_regulation (elevation) of ACTH Binding (association) of in EPI associated with heart rate under development, antagonist, opioid receptor and withdrawal
3) Confidence 0.49 Published 2003 Journal Int Clin Psychopharmacol Section Abstract Doc Link 12920386 Disease Relevance 1.03 Pain Relevance 0.57
Receptors encoded by the variant 118G polymorphism in exon 1 of the mu opioid receptor gene have a threefold increase in beta-endorphin binding and beta-endorphin is three times more potent in receptor-mediated activation of G protein-coupled inwardly rectifying potassium channels.
Positive_regulation (increase) of beta-endorphin Binding (binding) of associated with mu opioid receptor and potassium channel
4) Confidence 0.46 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16794569 Disease Relevance 0.27 Pain Relevance 0.27
The beta-endorphin binding did not affect the production of cAMP, but was enhanced by dexamethasone pretreatment.
Neg (not) Positive_regulation (enhanced) of beta-endorphin Binding (binding) of associated with dexamethasone
5) Confidence 0.44 Published 1995 Journal Exp. Cell Res. Section Abstract Doc Link 7641799 Disease Relevance 0.17 Pain Relevance 0.53
This N40D mutation, which has been implicated in the development of opioid addiction, was previously reported to result in an increased beta-endorphin binding affinity and a decreased potency of morphine-6-glucuronide.
Positive_regulation (increased) of beta-endorphin Binding (affinity) of associated with reprotox - general 2, addiction, opioid, morphine and potency
6) Confidence 0.44 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086512 Disease Relevance 0.20 Pain Relevance 0.73
The interaction of beta H-endorphin with S protein bore characteristics of a ligand-receptor interaction, such as time dependence, reversibility, high affinity, saturability, and structural specificity and was mediated through the non-opioid COOH terminus of the beta H-endorphin molecule. beta H-Endorphin binding to S protein was observed at physiological pH or cation concentrations, indicating that the interaction may well occur in vivo.
Positive_regulation (mediated) of H-endorphin Binding (interaction) of associated with addiction and opioid
7) Confidence 0.38 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.22
Inflammation of the paw tissue massively increased human beta-endorphin binding on both sides of the sciatic nerve ligature and in the ipsilateral paw tissue.
Positive_regulation (increased) of beta-endorphin Binding (binding) of in sciatic nerve associated with inflammation and sciatic nerve
8) Confidence 0.38 Published 1993 Journal Neuroscience Section Abstract Doc Link 7688879 Disease Relevance 0.34 Pain Relevance 0.86
This study investigated whether epidural analgesia (EDA) influences the migration of beta-endorphin (END) and/or met-enkephalin (ENK)-containing leukocytes into the subcutaneous wound tissue of patients undergoing abdominal surgery.
Spec (whether) Positive_regulation (influences) of beta-endorphin Binding (migration) of in leukocytes associated with injury, epidural, enkephalin and analgesia
9) Confidence 0.10 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17174527 Disease Relevance 0.39 Pain Relevance 1.28

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