INT248206

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 15
Total Number 63
Disease Relevance 9.17
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
granule cells 24
hippocampus 4
tail 3
brain 3
plasma 2
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 101 100.00 Very High Very High Very High
Hippocampus 1318 99.92 Very High Very High Very High
fluoxetine 259 99.86 Very High Very High Very High
antidepressant 134 99.76 Very High Very High Very High
Central nervous system 147 99.38 Very High Very High Very High
midbrain 48 97.44 Very High Very High Very High
sSRI 49 96.04 Very High Very High Very High
GABAergic 49 89.40 High High
Glutamate 49 86.88 High High
gABA 343 86.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 191 100.00 Very High Very High Very High
Congenital Anomalies 87 99.80 Very High Very High Very High
Neurodegenerative Disease 734 98.20 Very High Very High Very High
Anxiety Disorder 362 96.52 Very High Very High Very High
Shock 10 90.64 High High
Affective Disorder 51 89.48 High High
Schizophrenia 241 88.56 High High
Mental Disorders 44 87.20 High High
Autism 36 81.32 Quite High
Depression 184 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is possible to speculate that TDO expressed in hippocampal mature neurons seems to be beneficial to protect from excitotoxicity by the synthesis of neuroprotective metabolites of the kynurenine pathway, such as kynurenine and kynurenic acid, which suppress N-methyl-D-aspartate (NMDA) and ?
Gene_expression (expressed) of TDO in neurons
1) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.11 Pain Relevance 0.26
Furthermore, we demonstrated that mature DG granule cells strongly express TDO.
Gene_expression (express) of TDO in granule cells
2) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.12 Pain Relevance 0.39
Considering that the expression of TDO protein can be detected predominantly in the mature neurons, the rise in 5-HT may act on the neural stem cells/neural progenitor cells in Tdo-/- mice, and TDO may function in the mature granule cells as described below.
Gene_expression (expression) of TDO in stem cells
3) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.24 Pain Relevance 0.48
As described above, the immunohistochemical study showed that TDO was expressed in a part of immature granule cells and mature ones.
Gene_expression (expressed) of TDO in granule cells
4) Confidence 0.78 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
It should be noted that tdo and its variants mRNAs are expressed in various regions of developing and adult brain [34], suggesting a possible role of locally expressed TDOs in the brain for the specific regional modulation of the brain and subsequent behavioral modulation.
Gene_expression (expressed) of tdo in brain
5) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.88 Pain Relevance 0.21
As TDO is predominantly expressed in the liver, we briefly looked at gross liver morphology: although little difference between 13-week-old Tdo-/- and Tdo+/+ mice was seen, confirmation of a lack of effect on the histological status of the liver will require further detailed examination.


Gene_expression (expressed) of TDO in liver
6) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.37 Pain Relevance 0
To determine when TDO was expressed during the development of granule cells, we performed BrdU labeling of granule cells.
Gene_expression (expressed) of TDO in granule cells
7) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
These results of TDO expression in the SVZ, the OB, and the cerebellum seem to be similar to those in the Allen Brain Atlas http://www.brain-map.org/, a database of gene expressions by in situ hybridization [19].


Gene_expression (expression) of TDO in Atlas
8) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.05
Reduced TDO expression in the granule cells of CaMKII?
Gene_expression (expression) of TDO in granule cells
9) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
In the DG of wild-type littermate mice, TDO were expressed in the granule cells (Fig. 8A).
Gene_expression (expressed) of TDO in granule cells
10) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Next, we addressed if TDO was expressed in the SVZ.
Gene_expression (expressed) of TDO
11) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.13
TDO+ cells comprised 284 of 1629 calretinin+ (17.7 ± 6.33%, n = 4 mice) and 2332 of 2354 calbindin+ cells (99.1 ± 0.787%, n = 4 mice; Fig. 4), suggesting that some immature granule cells, which might be at the late-stage of development, and mature cells express TDO.
Gene_expression (express) of TDO in granule cells
12) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.06
TDO expression increased dramatically after 2 wk of age.
Gene_expression (expression) of TDO
13) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
We next examined the expression of TDO in mature cells using CaMKII?
Spec (examined) Gene_expression (expression) of TDO
14) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
The findings described above indicate that TDO is expressed mainly in mature granule cells.
Gene_expression (expressed) of TDO in granule cells
15) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
+/- mice and the higher expression of tdo in the hippocampus compared with several regions of the central nervous system [12], it can be inferred that TDO might be expressed only after a certain stage of granule cell differentiation in the normal mouse.
Gene_expression (expression) of tdo in granule cell associated with central nervous system and hippocampus
16) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.29 Pain Relevance 0.29
The TDO-immunoreactive structures in the olfactory bulb (OB), where neuroblasts derived from the SVZ migrate and differentiate to granule cells and periglomerular cells, were hardly observed, indicating that TDO may not be expressed in the SVZ-OB system.
Neg (not) Gene_expression (expressed) of TDO in granule cells
17) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.11
Since TDO was expressed in the mature granule cells of the dentate gyrus, it does not seem to play a role in the development of the dentate granule cells.
Gene_expression (expressed) of TDO in granule cells
18) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.33 Pain Relevance 0.20
+/- mice, the decreased expression of TDO may be due to the lack of mature granule cells in CaMKII?
Gene_expression (expression) of TDO in granule cells
19) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Furthermore, we examined if another brain region, cerebellum, that contains granule cells express TDO.
Gene_expression (express) of TDO in granule cells
20) Confidence 0.68 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.09

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