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Context Info
Confidence 0.82
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.17
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
brains 1
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 67 92.60 High High
antidepressant 62 80.16 Quite High
depression 74 79.40 Quite High
midbrain 9 32.32 Quite Low
Eae 26 6.36 Low Low
fluoxetine 19 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
Dopamine 7 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 91.52 High High
Depression 96 85.16 High High
Retts Disease 68 84.64 Quite High
Suicidal Behaviour 123 76.64 Quite High
Stress 31 64.40 Quite High
Body Weight 8 55.68 Quite High
Injury 1 54.60 Quite High
Cognitive Disorder 7 52.60 Quite High
Anxiety Disorder 24 48.08 Quite Low
Tremor 4 47.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, we observed decreased expression of synaptic proteins in brains of Mecp2?
Phosphorylation (brains) of Mecp2 in brains
1) Confidence 0.82 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.27 Pain Relevance 0
Comparison of life span of Mecp2?
Phosphorylation (span) of Mecp2
2) Confidence 0.82 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.06 Pain Relevance 0
Also, Greenberg and colleagues reported that activity-dependent phosphorylation of MeCP2 at serine 421 is mediated by CaMKII and phosphorylation of the site controls the ability of MeCP2 to regulate activity-dependent BDNF transcription and dendritic growth [35], raising the possibility that the immature DG of the mutant mice is due to a disruption of the program that regulates gene expression triggered by this pathway.
Phosphorylation (phosphorylation) of MeCP2
3) Confidence 0.55 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0 Pain Relevance 0.08
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Phosphorylation (phosphorylation) of MeCP2 associated with repression
4) Confidence 0.22 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.84 Pain Relevance 0.18

General Comments

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