INT248209

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Camk2a, Mecp2) enzyme binding (Mecp2) embryo development (Mecp2)
DNA binding (Mecp2) protein complex (Mecp2) response to stress (Mecp2)
Camk2a (Mus musculus)
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 92.60 High High
Eae 18 6.36 Low Low
Dopamine 7 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 35 45.88 Quite Low
Congenital Anomalies 7 13.76 Low Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 7 5.00 Very Low Very Low Very Low
Shock 5 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, Greenberg and colleagues reported that activity-dependent phosphorylation of MeCP2 at serine 421 is mediated by CaMKII and phosphorylation of the site controls the ability of MeCP2 to regulate activity-dependent BDNF transcription and dendritic growth [35], raising the possibility that the immature DG of the mutant mice is due to a disruption of the program that regulates gene expression triggered by this pathway.
CaMKII Positive_regulation (mediated) of Phosphorylation (phosphorylation) of MeCP2
1) Confidence 0.52 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0 Pain Relevance 0.08

General Comments

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