INT248236

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FN1, SDC1) small molecule metabolic process (SDC1) protein complex (SDC1)
lipid metabolic process (SDC1) cytoplasm (SDC1) cytoskeletal protein binding (SDC1)
Anatomy Link Frequency
leukocyte 1
FN1 (Homo sapiens)
SDC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 8 89.72 High High
cytokine 3 88.62 High High
Arthritis 26 65.72 Quite High
rheumatoid arthritis 39 65.40 Quite High
Inflammation 7 63.64 Quite High
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 90.78 High High
Disease 6 69.52 Quite High
Seronegative Spondarthritis 24 65.72 Quite High
Rheumatoid Arthritis 39 65.40 Quite High
INFLAMMATION 8 63.64 Quite High
Osteoarthritis 14 59.28 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low
Carcinoma 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Synovitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HSPGs act as co-receptors for cytokines and are involved in presenting chemokines to chemokine receptors.1 30 58 In addition, HSPGs act as adhesion molecules, playing an important role in cell–matrix and cell–cell interactions.4 29 These functions are due to interactions with the heparan sulphate chains but may also include the core protein.29 42 The role of the core protein of HSPGs is becoming increasingly apparent, not only determining when and where the heparan sulphate chains are expressed but also playing a direct role in signalling.59 Cell–matrix interactions have been shown for syndecan-3 and syndecan-1 that interact with extracellular molecules such as collagen and fibronectin.4 The presence of syndecan-3 on macrophages and syndecan-1 on plasma cells suggests that these HSPGs may be involved in leukocyte–matrix interactions leading to the accumulation of these cells in the inflamed synovial tissue.
fibronectin Binding (interact) of syndecan-1 in leukocyte associated with chemokine, adhesions and cytokine
1) Confidence 0.00 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.76 Pain Relevance 0.41

General Comments

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