INT248237

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC3) signal transduction (IL8) extracellular space (IL8)
extracellular region (IL8) cell adhesion (SDC3) intracellular (IL8)
Anatomy Link Frequency
leukocyte 1
IL8 (Homo sapiens)
SDC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 8 100.00 Very High Very High Very High
rheumatoid arthritis 39 94.52 High High
Arthritis 26 28.00 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 94.52 High High
Ovarian Cancer 1 94.00 High High
Malignant Neoplastic Disease 1 90.60 High High
Adhesions 4 87.64 High High
Carcinoma 2 86.92 High High
Cancer 2 48.36 Quite Low
Disease 6 32.40 Quite Low
Seronegative Spondarthritis 24 28.00 Quite Low
Osteoarthritis 14 26.80 Quite Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial syndecan-3 selectively binds the chemokine CXCL8, suggesting a role in leukocyte trafficking into the synovium, whereas syndecan-2 and glypican-4 do not appear to bind this chemokine despite the presence of these HSPGs in the synovial endothelium.14 A role for syndecan-3 in leukocyte extravasation is further suggested since heparan sulphate can act as an adhesion molecule involved in blood leukocyte-endothelial interactions.51 In the current study syndecan-3 was not purely a marker of endothelial cells since it also localised to CD68+ macrophages in the sublining.
CXCL8 Binding (binds) of syndecan-3 in leukocyte associated with chemokine and adhesions
1) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.52 Pain Relevance 0.18

General Comments

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