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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.57
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC2) signal transduction (IL8) extracellular space (IL8)
extracellular region (IL8) intracellular (IL8) biological_process (SDC2)
Anatomy Link Frequency
umbilical vein 1
IL8 (Homo sapiens)
SDC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 8 99.98 Very High Very High Very High
Inflammatory response 1 98.40 Very High Very High Very High
Inflammation 7 95.48 Very High Very High Very High
rheumatoid arthritis 39 93.56 High High
cytokine 3 81.16 Quite High
Arthritis 26 73.84 Quite High
Pain 1 55.20 Quite High
Central nervous system 1 45.76 Quite Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 98.20 Very High Very High Very High
Targeted Disruption 1 95.98 Very High Very High Very High
Rheumatoid Arthritis 39 93.56 High High
Hypertrophy 1 83.36 Quite High
Adhesions 4 76.64 Quite High
Seronegative Spondarthritis 24 73.84 Quite High
Rheumatic Diseases 1 67.56 Quite High
Disease 6 61.20 Quite High
Congenital Anomalies 1 58.20 Quite High
Pain 1 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is increasing evidence that HSPGs are involved in inflammation.18 Using animal knockout models and isolated cells, syndecan-1 and syndecan-4 have been shown to be involved in regulating inflammatory responses,19 binding chemokines20 21 and forming chemokine gradients.22 23 The chemokine CXCL8 has been shown to bind to syndecan-2 in cultured human umbilical vein endothelial cells24 and we recently showed the induction of a CXCL8 binding site on syndecan-3 in the endothelial cells of the RA synovium.14 However, little is known about the expression of syndecans and glypicans by the various cell types of the chronically inflamed synovium, although other proteoglycans bearing GAGs such as dermatan sulphate have been identified in this tissue.25 HSPGs are of interest as they are co-receptors for cytokines (eg, fibroblast growth factor), presenters of chemokines and are involved in cell–matrix and cell–cell adhesion.26–30 Hence they are likely candidates involved in several pathomechanisms in chronically inflamed synovia, such as angiogenesis and the migration and retention of leukocytes.
CXCL8 Binding (bind) of syndecan-2 in umbilical vein associated with targeted disruption, chemokine, inflammatory response, inflammation, rheumatoid arthritis, adhesions and cytokine
1) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 1.57 Pain Relevance 0.72

General Comments

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