INT248259

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSPG2) intracellular (Gtf3a) DNA binding (Gtf3a)
extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2) extracellular space (HSPG2)
Anatomy Link Frequency
brain 1
HSPG2 (Homo sapiens)
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 39 98.08 Very High Very High Very High
Arthritis 26 70.20 Quite High
chemokine 8 18.00 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 98.08 Very High Very High Very High
Cancer 2 95.28 Very High Very High Very High
Seronegative Spondarthritis 24 70.20 Quite High
Carcinoma 2 47.60 Quite Low
Malignant Neoplastic Disease 1 40.16 Quite Low
Osteoarthritis 14 35.12 Quite Low
Ovarian Cancer 1 33.76 Quite Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of syndecan-2 has been shown in mesenchymal, neuronal and cancer cells.45 46 In line with our results this HSPG has also been found in endothelial cells, for example in the brain where it is highly expressed.47 There is evidence that syndecan-2 is involved in angiogenesis that may be related to the interaction of the HSPG with vascular endothelial growth factor.48 This is of particular interest since in the RA synovium angiogenesis is a significant pathological event responsible for its enlargement and invasive properties, and suggests an involvement of syndecan-2 in these mechanisms.
HSPG Binding (interaction) of factor in brain associated with cancer and rheumatoid arthritis
1) Confidence 0.00 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.33 Pain Relevance 0.12

General Comments

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