INT248266

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
lung 2
Pde4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 89.20 High High
Inflammation 62 76.32 Quite High
fibrosis 2 64.12 Quite High
cytokine 24 53.08 Quite High
headache 2 40.56 Quite Low
abdominal pain 2 38.24 Quite Low
chemokine 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 96.56 Very High Very High Very High
Hyperoxia 98 93.52 High High
Weight Gain 24 85.48 High High
Vomiting 8 84.40 Quite High
Body Weight 8 81.96 Quite High
Lung Injury 4 80.88 Quite High
Bronchopulmonary Dysplasia 20 77.36 Quite High
INFLAMMATION 58 76.32 Quite High
Pulmonary Fibrosis 2 64.12 Quite High
Toxicity 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data allow us to conclude unequivocally to a significant effect of PDE4 inhibition independent of oxygen exposure.
Negative_regulation (effect) of Negative_regulation (inhibition) of PDE4
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.88 Pain Relevance 0.07
In their former study, de Visser and coworkers [15] argued for a beneficial effect of PDE4 inhibitors on lung histopathology because they found decreases in septal thickness and alveolar edema despite an absence of effect of PDE4 inhibitors on changes induced by hyperoxia in mean linear intercept.
Negative_regulation (effect) of Negative_regulation (inhibitors) of PDE4 in lung associated with pressure and volume under development and hyperoxia
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.98 Pain Relevance 0.20

General Comments

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