INT248271

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, Crp) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 2
liver 2
IL6 (Homo sapiens)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 99.90 Very High Very High Very High
Inflammatory response 2 99.40 Very High Very High Very High
Inflammation 29 97.72 Very High Very High Very High
spinal inflammation 43 93.64 High High
imagery 41 88.88 High High
metalloproteinase 1 85.08 High High
Infliximab 34 63.28 Quite High
Arthritis 3 33.00 Quite Low
rheumatoid arthritis 3 32.80 Quite Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 53 100.00 Very High Very High Very High
Acute-phase Reaction 2 100.00 Very High Very High Very High
INFLAMMATION 49 99.22 Very High Very High Very High
Atherosclerosis 7 91.60 High High
Death 1 87.20 High High
Low Back Pain 33 76.32 Quite High
Shock 2 75.44 Quite High
Thrombocytopenia 8 68.40 Quite High
Hantavirus Infection 47 50.00 Quite Low
Diabetes Mellitus 15 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ROS can activate the transcription factor NF-kB, that is ubiquitously expressed and mediates the expression of genes involved in the acute inflammatory response, including the cytokines IL1-IL6 and IL8 [23], which in turn modulate CRP production.
IL6 Regulation (modulate) of Gene_expression (production) of CRP associated with inflammatory response and cytokine
1) Confidence 0.27 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.60 Pain Relevance 0.20
Tables 2 and 3 show the associations of various variables reflecting the severity of the disease with plasma IL-6 and CRP levels in patients divided into four groups according to maximum IL-6 and CRP values.
IL-6 Regulation (reflecting) of Gene_expression (levels) of CRP in plasma associated with disease
2) Confidence 0.12 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2885391 Disease Relevance 0.33 Pain Relevance 0
In this regard, it is noteworthy that IL-6 is thought to be involved in the initiation of the acute phase response and the production of CRP in the liver.35 IL-6 polymorphisms have been shown to be associated with CRP levels in other conditions.8 9
IL-6 Regulation (involved) of Gene_expression (production) of CRP in liver associated with acute-phase reaction
3) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.78 Pain Relevance 0.53

General Comments

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