INT248297

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.96
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
CII 2
coronary artery 1
immune system 1
T cells 1
microglial cells 1
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 365 100.00 Very High Very High Very High
tolerance 89 98.16 Very High Very High Very High
antagonist 11 91.00 High High
cytokine 132 90.12 High High
Inflammatory mediators 2 86.60 High High
cva 22 81.76 Quite High
corticosteroid 6 81.76 Quite High
rheumatoid arthritis 171 80.32 Quite High
ischemia 7 73.60 Quite High
Inflammation 86 59.04 Quite High
Disease Link Frequency Relevance Heat
Arthritis 156 100.00 Very High Very High Very High
Immunization 123 100.00 Very High Very High Very High
Targeted Disruption 31 99.74 Very High Very High Very High
Diabetes Mellitus 14 99.16 Very High Very High Very High
Disease 235 98.74 Very High Very High Very High
Cardiovascular Disease 18 98.24 Very High Very High Very High
Acute Coronary Syndrome 2 96.72 Very High Very High Very High
Experimental Arthritis 220 95.84 Very High Very High Very High
Autoimmune Disease 79 93.00 High High
Hypertension 7 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects seen after inhibition of CD40 might be attributable to a direct effect on CD40 in B cells or an indirect effect through lower activation of T cells.
Negative_regulation (inhibition) of CD40 in T cells
1) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.44 Pain Relevance 0.03
There was a highly significant decrease in serum levels of IgM-RF at 16 (p?
Negative_regulation (decrease) of IgM
2) Confidence 0.57 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.03
To confirm the functional inhibition of CD40 in microglia, we treated both N9 and primary microglial cells with 25 ?
Negative_regulation (inhibition) of CD40 in microglial cells
3) Confidence 0.51 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0.06
Indeed, DCs in RelB knockout mice, which lack CD40, have been demonstrated to induce infectious tolerance through induction of Treg cells [24].


Negative_regulation (lack) of CD40 associated with targeted disruption and tolerance
4) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.59 Pain Relevance 0.13
The current study evaluated a practical method of immune modulation through temporary systemic inhibition of the costimulatory molecule CD40.


Negative_regulation (inhibition) of CD40
5) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.38
While complete inhibition of disease was not observed, the finding that administration of siRNA even after disease initiation occurred was effective suggests that the temporary CD40 inhibition may have potent therapeutic effects.
Negative_regulation (inhibition) of CD40 associated with disease
6) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.50 Pain Relevance 0.04
This report is the first to our knowledge to describe systemic inhibition of CD40 by siRNA as a means of interrupting autoimmune processes in order to up-regulate the natural tendency of the immune system to re-equilibrate tolerogenic mechanisms.
Negative_regulation (inhibition) of CD40 in immune system
7) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.57 Pain Relevance 0.18
We consider that one attractive possible mechanism by which systemic CD40 inhibition mediates immune modulation is through the up-regulation of Treg cells.
Spec (possible) Negative_regulation (inhibition) of CD40
8) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.58 Pain Relevance 0.09
g CD40 siRNA two days before immunization with CII antigen and subsequently CD40 siRNA was administered on Day 7 after immunization with CII.
Negative_regulation (administered) of CD40 siRNA in CII associated with immunization
9) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.96 Pain Relevance 0.27
RNA inference may provide a novel approach to blocking the CD40 signal.
Negative_regulation (blocking) of CD40
10) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.08 Pain Relevance 0.40
Specific knockdown of CD40 mRNA and protein was seen in DCs by RT-PCR (Figure 1A), and flow cytometry (Figure 1B), respectively, as compared to DCs transfected with control scrambled siRNA.
Negative_regulation (knockdown) of CD40
11) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.27 Pain Relevance 0.08
g CD40 siRNA two days before immunization with CII antigen and subsequently CD40 siRNA was administered on Day 7 after immunization with CII.
Negative_regulation (administered) of CD40 siRNA in CII associated with immunization
12) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.95 Pain Relevance 0.27
Prevention of autoimmune arthritis by treatment with CD40 siRNA
Negative_regulation (Prevention) of CD40 siRNA associated with arthritis
13) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.57 Pain Relevance 0.24
Decreased IgM-RF and ACPA levels after rituximab treatment
Negative_regulation (Decreased) of IgM
14) Confidence 0.42 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.04
Treatment with rosiglitazone decreased the serum levels of soluble CD40 and MMP-9 in type 2 diabetic patients with coronary artery disease [53].
Negative_regulation (decreased) of CD40 in coronary artery associated with cardiovascular disease and diabetes mellitus
15) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.46 Pain Relevance 0.11

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