INT248308

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.48
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MATN3) proteinaceous extracellular matrix (MATN3)
MATN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 48 100.00 Very High Very High Very High
cINOD 7 96.24 Very High Very High Very High
Paracetamol 2 95.36 Very High Very High Very High
Pain 26 93.20 High High
rheumatoid arthritis 2 70.56 Quite High
adenocard 3 60.00 Quite High
Inflammation 12 55.08 Quite High
Arthritis 2 27.20 Quite Low
Pain scale 11 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 88 100.00 Very High Very High Very High
Osteoarthropathy 22 100.00 Very High Very High Very High
Pain 23 93.20 High High
Disease 49 92.00 High High
Osteoarthritis 28 78.36 Quite High
Rheumatoid Arthritis 3 70.56 Quite High
Bone Cancer 4 63.20 Quite High
INFLAMMATION 13 55.08 Quite High
Pressure And Volume Under Development 6 48.16 Quite Low
Arthritis 2 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the effect of these mutations on the secretion of matrilin-3 we cloned and expressed full-length wt, mutant (p.Val194Asp) and polymorphic (p.Glu252Lys) matrilin-3 in mammalian cells.
Regulation (effect) of Localization (secretion) of matrilin
1) Confidence 0.27 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.82 Pain Relevance 0
To determine the effect of MED mutations on the secretion of matrilin-3 we cloned and expressed in mammalian cells full-length wt matrilin-3 and matrilin-3 harboring a MED mutation (p.Val194Asp) and non-synonymous polymorphism (p.Glu252Lys).
Spec (determine) Regulation (effect) of Localization (secretion) of matrilin associated with osteochondrodysplasias
2) Confidence 0.27 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.67 Pain Relevance 0
For feasibility reasons we chose not to include other hand indexes that are alternatives to AUSCAN in the assessment of HOA.40 41
Regulation (alternatives) of Localization (assessment) of HOA associated with osteoarthritis
3) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 0.99 Pain Relevance 0.71

General Comments

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