INT248321

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 1
Speculated 4
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 10.73
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
adipose tissue 6
plasma 4
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 19 99.56 Very High Very High Very High
Inflammation 78 97.84 Very High Very High Very High
cytokine 22 94.60 High High
Infliximab 9 50.00 Quite Low
tolerance 45 40.32 Quite Low
cINOD 6 10.96 Low Low
methotrexate 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 270 100.00 Very High Very High Very High
Rheumatoid Arthritis 19 99.56 Very High Very High Very High
Diabetes Mellitus 110 98.98 Very High Very High Very High
Insulin Resistance 20 98.80 Very High Very High Very High
INFLAMMATION 84 97.84 Very High Very High Very High
Adhesions 12 74.40 Quite High
Disease 27 68.44 Quite High
Cancer 18 63.52 Quite High
Necrosis 8 50.00 Quite Low
Infection 10 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We could confirm our hypothesis that the level of synovial TNF?
Regulation (confirm) of Gene_expression (level) of synovial
1) Confidence 0.44 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.44 Pain Relevance 0.21
However, here we demonstrate that YKL-40 levels do not fluctuate with acute changes in plasma glucose or plasma insulin.
Neg (not) Regulation (fluctuate) of Gene_expression (levels) of YKL-40 in plasma
2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.10 Pain Relevance 0.04
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Spec (possible) Regulation (relationship) of Gene_expression (expression) of YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
3) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.30 Pain Relevance 0.35
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Spec (possible) Regulation (relationship) of Gene_expression (expression) of plasma YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
4) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.29 Pain Relevance 0.35
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Spec (possible) Regulation (relationship) of in plasma Gene_expression (expression) of YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
5) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.30 Pain Relevance 0.35
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Spec (possible) Regulation (relationship) of in plasma Gene_expression (expression) of plasma YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
6) Confidence 0.12 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.29 Pain Relevance 0.35

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