INT248325

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Aes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ziconotide 240 99.28 Very High Very High Very High
backache 2 95.28 Very High Very High Very High
Pain 38 93.44 High High
abdominal pain 2 90.96 High High
headache 4 88.16 High High
rheumatoid arthritis 32 87.56 High High
Infliximab 186 77.68 Quite High
abatacept 190 77.08 Quite High
intrathecal 104 70.28 Quite High
Rheumatism 4 57.60 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 5 95.80 Very High Very High Very High
Low Back Pain 2 95.28 Very High Very High Very High
Arthralgia 1 94.40 High High
Pain 52 93.44 High High
Syndrome 1 92.64 High High
Infection 34 91.84 High High
Abdominal Pain 2 90.96 High High
Injury 3 88.80 High High
Headache 4 88.16 High High
Rheumatoid Arthritis 32 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most frequently reported AEs (?
Positive_regulation (frequently) of Localization (reported) of AEs
1) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2908075 Disease Relevance 1.05 Pain Relevance 0.37
The relatively slow onset of AEs suggests that increments in the dosing of ziconotide be made no more frequently than weekly.33
Positive_regulation (increments) of Localization (onset) of AEs associated with ziconotide
2) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.08 Pain Relevance 1.01
All patients who received at least one dose of study drug were evaluated for safety, including all reported AEs, serious AEs (SAEs), and clinically significant changes in vital signs, physical exams, and clinical laboratory test abnormalities.
Positive_regulation (reported) of Localization (serious) of AEs associated with congenital anomalies
3) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564802 Disease Relevance 0.38 Pain Relevance 0.35
All patients who received at least one dose of study drug were evaluated for safety, including all reported AEs, serious AEs (SAEs), and clinically significant changes in vital signs, physical exams, and clinical laboratory test abnormalities.
Positive_regulation (reported) of Localization (serious) of AEs associated with congenital anomalies
4) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564802 Disease Relevance 0.38 Pain Relevance 0.35

General Comments

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