INT24836

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.44
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
hippocampus 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 10 100.00 Very High Very High Very High
Enkephalin 10 99.70 Very High Very High Very High
antagonist 2 98.90 Very High Very High Very High
Hippocampus 4 98.84 Very High Very High Very High
Dopamine 7 98.68 Very High Very High Very High
Substantia nigra 2 94.16 High High
Raphe 1 90.64 High High
Spinal cord 1 83.56 Quite High
Dynorphin 6 83.04 Quite High
gABA 3 82.96 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 97.48 Very High Very High Very High
Epilepsy 1 95.52 Very High Very High Very High
Convulsion 1 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glutamate NMDA receptor antagonist MK-801 reversed the nicotine-induced increase of Dyn, while the AMPA antagonist NBQX had a marginal effect.
Negative_regulation (reversed) of Positive_regulation (increase) of Dyn
1) Confidence 0.38 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18807250 Disease Relevance 0 Pain Relevance 0
The concurrent administration of the D1 DA antagonist, SCH-23390, or the D2 DA antagonist, spiperone, to the subchronic regimen of cocaine also blocked the cocaine-induced increase in DYN levels.
Negative_regulation (blocked) of Positive_regulation (increase) of DYN associated with dopamine, antagonist and cocaine
2) Confidence 0.11 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2476548 Disease Relevance 0 Pain Relevance 0.93
Ketogenic diet decreases the level of proenkephalin mRNA induced by kainic acid in the mouse hippocampus.
Negative_regulation (decreases) of Positive_regulation (induced) of proenkephalin mRNA in hippocampus associated with enkephalin and hippocampus
3) Confidence 0.07 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16300887 Disease Relevance 0.18 Pain Relevance 0.36
Moreover, c-fos ASO pretreatment significantly decreased the 5-HT-induced upregulation of ppDyn and ppEnk mRNAs, but failed to affect the expression level of GAD mRNA.
Negative_regulation (decreased) of Positive_regulation (upregulation) of ppDyn associated with generalized anxiety disorder
4) Confidence 0.01 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12963037 Disease Relevance 0.26 Pain Relevance 0.57

General Comments

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