INT248374

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 10.45
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
Anatomy Link Frequency
neuronal 1
astrocyte 1
nitrergic neurons 1
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 92 100.00 Very High Very High Very High
Pain 81 94.80 High High
Inflammation 3 79.40 Quite High
Snapping jaw 1 65.68 Quite High
backache 1 56.24 Quite High
Spinal cord 1 55.12 Quite High
Bioavailability 1 32.44 Quite Low
chemokine 1 31.56 Quite Low
cytokine 1 31.08 Quite Low
Fibrositis 3 20.48 Low Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 1026 100.00 Very High Very High Very High
Dyspepsia 92 100.00 Very High Very High Very High
Infection 3 98.76 Very High Very High Very High
Injury 1 98.48 Very High Very High Very High
Ulcers 3 98.32 Very High Very High Very High
Vomiting 26 96.64 Very High Very High Very High
Disease 78 96.32 Very High Very High Very High
Weight Loss 1 96.22 Very High Very High Very High
Pain 83 94.80 High High
Cancer 20 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that some transcription/splicing factors involved in IKBKAP exon 20 recognition are also downregulated in a tissue-specific manner.
IKBKAP exon 20 Binding (recognition) of
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.51 Pain Relevance 0
Moreover, kinetin, by improving IKBKAP exon 20 recognition, restores IKBKAP transcript levels in FD hOE-MSCs similar to those observed in control cells (Figure 7G).
IKBKAP exon 20 Binding (recognition) of associated with familial dysautonomia
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.24 Pain Relevance 0
B kinase complex-associated protein (IKAP).
IKAP Binding (kinase) of
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012102 Disease Relevance 0.67 Pain Relevance 0
Kinetin treatment corrects aberrant IKBKAP pre-mRNA splicing
IKBKAP pre-mRNA Binding (splicing) of
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.55 Pain Relevance 0
B kinase complex-associated protein (IKAP).
complex-associated protein Binding (kinase) of
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3012102 Disease Relevance 0.67 Pain Relevance 0
B kinase complex-associated protein (IKAP; for simplicity, IKAP is used rather than IKBKAP to refer to the mRNA encoded by this gene).
complex-associated protein Binding (kinase) of
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 1.09 Pain Relevance 0.09
B kinase complex-associated protein (IKAP; for simplicity, IKAP is used rather than IKBKAP to refer to the mRNA encoded by this gene).
IKAP Binding (refer) of
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 1.07 Pain Relevance 0.09
Both control and FD hOE-MSCs were able to form spheres in approximately one week, and immunostaining with anti-?
FD Binding (hOE) of associated with familial dysautonomia
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.55 Pain Relevance 0
Commitment of FD OE-MSCs into neuronal and glial lineages leads to a more severe IKBKAP exon 20 skipping
FD Binding (Commitment) of in neuronal associated with familial dysautonomia
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.53 Pain Relevance 0
As a consequence, the splicing machinery in neuron or astrocyte-differentiated cells is impaired for IKBKAP exon 20 recognition.


IKBKAP exon 20 Binding (recognition) of in astrocyte
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.56 Pain Relevance 0
Association of LiSat-11 domains and MPI-S subgroups AC, DYS, and ID
DYS Binding (Association) of
11) Confidence 0.05 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2564919 Disease Relevance 1.37 Pain Relevance 1.16
PI-FD is associated with persisting focal T-cell aggregates, decreased CD4+ cells and increased macrophages in the duodenum.13 Enterochromaffin cell counts are not altered in PI-FD.13 Early satiety, weight loss, nausea and vomiting are more frequently reported in patients with presumed PI-FD.53 Helicobacter pylori (H. pylori) infection, gastric emptying, and gastric sensitivity do not seem to be associated with PI-FD, whereas a high prevalence of impaired gastric accommodation is observed in patients with presumed PI-FD.54 This impairment is suggested to be attributable to a dysfunction at the level of gastric nitrergic neurons.
PI-FD Binding (associated) of in nitrergic neurons associated with weight loss, ulcers, vomiting, nud and infection
12) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912117 Disease Relevance 1.78 Pain Relevance 0.56
Firstly FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex.
FdUMP Binding (bind) of
13) Confidence 0.00 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886333 Disease Relevance 0.68 Pain Relevance 0

General Comments

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