INT248394

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CHD5) helicase activity (CHD5) DNA binding (CHD5)
Anatomy Link Frequency
melanocyte 2
Mouse 1
CHD5 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 4 7.20 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 12 100.00 Very High Very High Very High
Cancer 52 99.84 Very High Very High Very High
Aging 12 97.60 Very High Very High Very High
Hyperplasia 16 97.04 Very High Very High Very High
Melanoma 48 94.04 High High
Neuroblastoma 4 60.04 Quite High
Cutaneous Melanoma 12 30.92 Quite Low
Dysplastic Nevus Syndrome 8 14.32 Low Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also we did not possess a source of mRNA to study CHD5 expression in tumor or compare melanocyte expression of CHD5 between affected individuals and controls.
Gene_expression (expression) of CHD5 in melanocyte associated with cancer
1) Confidence 0.70 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.25 Pain Relevance 0
Also we did not possess a source of mRNA to study CHD5 expression in tumor or compare melanocyte expression of CHD5 between affected individuals and controls.
Gene_expression (expression) of CHD5 in melanocyte associated with cancer
2) Confidence 0.70 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.25 Pain Relevance 0
Mouse cells deficient in Chd5 due to loss of one copy by Cre-loxP-mediated recombination expressed decreased levels of p53, p16 and p19.
Gene_expression (deficient) of Chd5 in Mouse
3) Confidence 0.61 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.93 Pain Relevance 0
Subsequent experiments showed that Chd5 mediated apoptosis involved p53 and that Chd5 haploinsufficiency led to decreased expression of CDKN2A (p16) and p19 (human p14ARF-alternate-spliced exon 1?
Gene_expression (apoptosis) of Chd5 associated with apoptosis
4) Confidence 0.61 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.87 Pain Relevance 0

General Comments

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