INT248399

Context Info Confidence 0.37 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.71 Pain Relevance 0

nucleolus (CDKN1C) nucleus (CDKN1C) cell cycle (CDKN1C) cytoplasm (CDKN1C)

Anatomy Link Frequency angular 1 CDKN1C (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 4 5.00 Central nervous system 4 5.00 Spinal cord 3 5.00 Pain 2 5.00 cytokine 1 5.00 Multiple sclerosis 1 5.00 imagery 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Cancer 101 100.00 Beckwith-wiedemann Syndrome 76 100.00 Apoptosis 8 89.28 Renal Cancer 55 87.32 Reprotox - General 1 2 83.08 Metastasis 7 82.60 Adhesions 6 79.24 Hypoxia 7 71.04 Aging 13 50.00 Body Weight 13 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.

Negative_regulation (decrease) of BWS in angular associated with beckwith-wiedemann syndrome

1) Confidence 0.37 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 1.03 Pain Relevance 0

Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.

Negative_regulation (loss) of CDKN1C associated with hypoxia, cancer, apoptosis, adhesions and metastasis

2) Confidence 0.30 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.68 Pain Relevance 0

General Comments

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