INT248415

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.88
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 39 93.20 High High
Inflammation 8 91.60 High High
spastic colon 2 54.16 Quite High
depression 7 50.64 Quite High
Raphe 18 50.00 Quite Low
Raphe magnus 1 42.96 Quite Low
Dopamine 12 37.96 Quite Low
Neurobehavioral 2 18.80 Low Low
Neurotransmitter 16 10.16 Low Low
Eae 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 498 98.32 Very High Very High Very High
Hematological Disease 24 96.48 Very High Very High Very High
Targeted Disruption 204 93.24 High High
Disease 120 91.92 High High
INFLAMMATION 8 91.60 High High
Communicable Diseases 6 90.88 High High
Fatigue 72 86.08 High High
Death 12 81.08 Quite High
Cancer 18 80.60 Quite High
Functional Bowel Disorder 2 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative to the standard analysis candidates, the 20 IWGCNA genes had a moderate association with severity, and stronger associations with the TPH2 SNP and MEblue.
TPH2 Binding (associations) of
1) Confidence 0.44 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.28 Pain Relevance 0
The severity association with the TPH2 SNP was very significant for all samples combined (p-value = 0.010), the male samples (p-value = 0.030), and moderately significant in the female samples after homogenization (p-value = 0.076).
TPH2 Binding (association) of
2) Confidence 0.44 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.28 Pain Relevance 0.04
In addition to belonging to a severity-related module the 20 IWGCNA candidate genes also a) had a high association with the TPH2 locus, b) high intramodular connectivity, and c) were related to CFS severity in both sexes.
TPH2 Binding (association) of associated with chronic fatigue syndrome
3) Confidence 0.44 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.60 Pain Relevance 0
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
TPH2 Binding (Generation) of
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
TPH2 Binding (Generation) of
5) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
The TPH2 SNP was associated with severity (p-value = 0.010) and moderately associated with the blue module gene expressions (p-value = 0.077).
TPH2 Binding (associated) of
6) Confidence 0.34 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.35 Pain Relevance 0.05
We investigated the TPH2 SNP's contribution to our gene screening strategy by repeating the candidate gene IPA with TPH2 included.
TPH2 Binding (contribution) of
7) Confidence 0.34 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.86 Pain Relevance 0.05
The TPH2 SNP was associated with severity (p-value = 0.010) and moderately associated with the blue module gene expressions (p-value = 0.077).
TPH2 Binding (associated) of
8) Confidence 0.34 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.35 Pain Relevance 0.04
For Tph2 and ?
Tph2 Binding (For) of
9) Confidence 0.32 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0

General Comments

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