INT248418

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.45
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Anatomy Link Frequency
brain 1
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 103 100.00 Very High Very High Very High
sSRI 4 97.56 Very High Very High Very High
Catecholamine 2 91.24 High High
Neuropathic pain 14 90.72 High High
antidepressant 22 90.44 High High
tramadol 1 86.60 High High
MU agonist 1 86.24 High High
Pain 26 85.52 High High
Analgesic 3 84.24 Quite High
midbrain 15 79.56 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 166 100.00 Very High Very High Very High
Nociception 38 99.60 Very High Very High Very High
Targeted Disruption 101 96.56 Very High Very High Very High
Sprains And Strains 146 94.80 High High
Fatigue 24 92.88 High High
Neuropathic Pain 19 90.72 High High
Pain 25 85.52 High High
Congenital Anomalies 5 81.36 Quite High
Stress 11 77.40 Quite High
Disease 43 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, deletion of Tph2 alone produced rather subtle behavioral changes; these were strongly enhanced in the DKO mice.
Localization (deletion) of Tph2 associated with targeted disruption
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.50 Pain Relevance 0.15
In the brain, serotonin is produced by neuronal tryptophan hydroxylase Tph2 [12] which also accounts for serotonin synthesis in dorsal root ganglia [11] and is localized within a nociceptive quantitative trait locus [13].
Localization (localized) of Tph2 in brain associated with nociception and serotonin
2) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987995 Disease Relevance 0.72 Pain Relevance 0.89
We chose to focus on SNP rs10784941 located within the TPH2 tryptophan hydroxylase 2 gene because it had previously been shown to be associated with chronic fatigue, and it was associated with CFS severity in our data set [38,39].
Localization (located) of TPH2 associated with chronic fatigue syndrome
3) Confidence 0.68 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.45 Pain Relevance 0.03
We considered 36 autosomal SNPs that the CDC had selected from eight candidate CFS genes, TPH2 (SNPs selected from locus 12q21), POMC (2p24), NR3C1 (5q34), CRHR2 (7p15), TH (11p15), SLC6A4 (17q11.1), CRHR1 (17q21), COMT (22q11.1) [38].
Localization (selected) of TPH2 associated with chronic fatigue syndrome
4) Confidence 0.68 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.19 Pain Relevance 0
To address this possibility, we looked for an association between SNP variants and TST immobility for known coding SNPs in Tph2, Slc6a4, all serotonin receptors, and the genes for corticotrophin releasing hormone (Crh) and the Crh receptors.
Localization (immobility) of Tph2 associated with serotonin
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.60 Pain Relevance 0.37

General Comments

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