INT248419

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.32
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Anatomy Link Frequency
brain 2
body 1
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 133 97.68 Very High Very High Very High
Serotonin 193 96.44 Very High Very High Very High
antidepressant 112 90.04 High High
Raphe 109 83.28 Quite High
Analgesic 14 81.20 Quite High
medulla 16 71.16 Quite High
Central nervous system 11 70.64 Quite High
Neurotransmitter 61 68.96 Quite High
sSRI 68 67.20 Quite High
Hyperalgesia 7 66.88 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 83 99.88 Very High Very High Very High
Targeted Disruption 675 99.80 Very High Very High Very High
Body Weight 24 99.38 Very High Very High Very High
Anxiety Disorder 97 98.64 Very High Very High Very High
Manic Depressive Disorder 4 95.20 Very High Very High Very High
Affective Disorder 29 94.04 High High
Death 2 93.96 High High
Muscle Weakness 1 92.60 High High
Fatigue 12 91.80 High High
Disease 20 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The availability of mice with genetic disruption of TPH2 and TPH1/TPH2 provides biologists with a set of important tools for better understanding the roles of serotonin in mammalian physiology and behavior.


Negative_regulation (disruption) of TPH2 associated with serotonin
1) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.37 Pain Relevance 0.16
In a recent report, a TPH2 knockin mouse line with reduced TPH2 activity and an 80% reduction in brain 5-HT, due to a rare human SNP (R441H), was reported to have significantly increased immobility times in the TS [43].
Negative_regulation (reduced) of TPH2 in brain associated with targeted disruption
2) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.81 Pain Relevance 0.83
The availability of mice with genetic disruption of TPH2 and TPH1/TPH2 provides biologists with a set of important tools for better understanding the roles of serotonin in mammalian physiology and behavior.


Negative_regulation (disruption) of TPH2 associated with serotonin
3) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.37 Pain Relevance 0.16
In a recent report, a TPH2 knockin mouse line with reduced TPH2 activity and an 80% reduction in brain 5-HT, due to a rare human SNP (R441H), was reported to have significantly increased immobility times in the TS [43].
Negative_regulation (reduction) of TPH2 in brain associated with targeted disruption
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.83 Pain Relevance 0.85
To our knowledge this is the first report with full phenotypic evaluation of mice with genetic deletion of Tph2 and of both Tph isoforms.


Negative_regulation (deletion) of Tph2
5) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.60 Pain Relevance 0.08
Our data showed that 5-HT level in Lmx1b iCKO mice was reduced to 60% of control mice probably due to down-regulation of Tph2.
Negative_regulation (regulation) of Tph2
6) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10
As we showed in the present study, the inactivation of Lmx1b in adulthood led to a reduction in central 5-HT levels, probably as a consequence of Tph2 down-regulation.
Negative_regulation (regulation) of Tph2
7) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
As we showed in the present study, the inactivation of Lmx1b in adulthood led to a reduction in central 5-HT levels, probably as a consequence of Tph2 down-regulation.
Negative_regulation (down) of Tph2
8) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.07
A standard analysis of chronic fatigue syndrome that excludes the TPH2 SNP marker and module membership
Negative_regulation (excludes) of TPH2 associated with chronic fatigue syndrome
9) Confidence 0.39 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 1.44 Pain Relevance 0
The trend for the reduction in center time in the TPH2KO may be an indicator of increased anxiety.
Negative_regulation (reduction) of TPH2KO associated with anxiety disorder
10) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.70 Pain Relevance 0.19
Post-hoc analysis revealed that body weight and length were significantly decreased in TPH2KO and DKO males, compared to WT males.
Negative_regulation (decreased) of TPH2KO in body associated with targeted disruption and body weight
11) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 1.02 Pain Relevance 0
A genetic polymorphism of the promoter, rs11178997, reduces TPH2 transcriptional activity by 22% [104].
Negative_regulation (reduces) of TPH2
12) Confidence 0.26 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.09 Pain Relevance 0.05
The SNP C2755A changes the amino acid from serine to tyrosine at peptide position 41; the tyrosine coding allele reduces the activity of TPH2 by about 35% [19].
Negative_regulation (reduces) of TPH2
13) Confidence 0.19 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.10 Pain Relevance 0.03

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