INT24845

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 11.42
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gnptg) Golgi apparatus (Gnptg)
Anatomy Link Frequency
liver 3
lymphocyte 1
Gnptg (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 126 92.40 High High
Inflammation 117 79.96 Quite High
Pain 4 78.32 Quite High
cytokine 35 71.60 Quite High
agonist 53 63.68 Quite High
alcohol 19 62.72 Quite High
rheumatoid arthritis 7 62.28 Quite High
fibrosis 16 38.80 Quite Low
palliative 1 25.00 Low Low
halothane 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 7 99.84 Very High Very High Very High
Autoimmune Hepatitis 480 99.64 Very High Very High Very High
Liver Disease 35 99.36 Very High Very High Very High
Body Weight 30 99.04 Very High Very High Very High
Sprains And Strains 66 98.64 Very High Very High Very High
Diabetes Mellitus 25 98.36 Very High Very High Very High
Apoptosis 107 98.32 Very High Very High Very High
Bullous Skin Disease 7 97.80 Very High Very High Very High
Toxicity 84 97.48 Very High Very High Very High
Autoimmune Disease 133 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, even through such negative judgements can be expressed on TCE, both technical and clinical results have been, in our experience, quite satisfactory, which calls for optimization of the methodology.
Gene_expression (expressed) of TCE
1) Confidence 0.48 Published 1989 Journal Radiol Med Section Abstract Doc Link 2476839 Disease Relevance 0.49 Pain Relevance 0.26
TCA and TCE levels were below the detection limit in all control mice (Table 1).
Gene_expression (levels) of TCE
2) Confidence 0.09 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.48 Pain Relevance 0
TCA and TCE were detectable in all TRI-exposed mice but were not significantly different between the two TRI exposures within strains.
Gene_expression (detectable) of TCE associated with sprains and strains
3) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.49 Pain Relevance 0
TCA concentrations were significantly lower and TCE concentrations tended to be higher in exposed Ppar?
Gene_expression (concentrations) of TCE
4) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.44 Pain Relevance 0
These results, along with evidence that hepatic CYP2E1 expression and levels of TRI metabolites (TCA and TCE) were comparable among the three strains, may be consistent with a role of hepatic CYP2E1 in TRI-induced hepatic damage.
Gene_expression (expression) of TCE associated with sprains and strains
5) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.35 Pain Relevance 0.07
No analysis was reported to determine a statistical difference in proliferation between the two types of mice as a consequence of TCE exposure.
Gene_expression (exposure) of TCE
6) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 1.24 Pain Relevance 0
Fig. 5D shows that the three constructs express the recombinant VEGF RNA (total cell extract, TCE).
Gene_expression (express) of TCE
7) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.20 Pain Relevance 0
The authors reported that of the 43 genes with altered expression in wild-type mice after TCE exposure, 40 genes were dependent on PPAR ?.
Gene_expression (expression) of TCE
8) Confidence 0.05 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.74 Pain Relevance 0
Taken together these results showed that TCE exposure induced AIH, complete with lymphocyte infiltration and generation of antiliver antibodies, in MRL+/+ mice.

7.

Gene_expression (exposure) of TCE in lymphocyte associated with autoimmune hepatitis
9) Confidence 0.05 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.07 Pain Relevance 0
In a second mechanism TCE, through the generation of the TCE-O-P450 active metabolite, generates liver adducts.
Gene_expression (generation) of TCE in liver
10) Confidence 0.05 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.87 Pain Relevance 0.29
TCE exposure in mice also expanded the percentage of activated IFN-?
Gene_expression (exposure) of TCE
11) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.14 Pain Relevance 0.05
One of the primary dichloroacetyl lysine-adducted protein was found to be CYP2E1, the main enzyme for TCE oxidative metabolism.
Gene_expression (metabolism) of TCE
12) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.74 Pain Relevance 0.03
There are also links between TCE exposure and autoimmune liver diseases.
Gene_expression (exposure) of TCE in liver associated with liver disease
13) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.19 Pain Relevance 0
We found that female MRL+/+ mice exposed to low, occupationally relevant concentrations of TCE in their drinking water (2.5?
Gene_expression (concentrations) of TCE
14) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.15 Pain Relevance 0.07
Once ingested, some TCE is stored in adipose tissue, but most TCE is quickly distributed to the liver.
Gene_expression (stored) of TCE in liver associated with obesity
15) Confidence 0.04 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.82 Pain Relevance 0.03

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