INT248469

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Anatomy Link Frequency
HeLa 1
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 94.00 High High
Spinal Muscular Atrophy 96 73.48 Quite High
Coagulation Disorder 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Immunodeficiency 3 5.00 Very Low Very Low Very Low
Epidermolysis Bullosa Simplex 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Cystic Fibrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether ASO-enhanced trans-splicing occurred in a more complex context of endogenous SMN gene expression, pIn711 and pM13 was co-transfected into HeLa cells to examine trans-splicing with endogenous SMN transcripts.
SMN Spec (examine) Binding (endogenous) of in HeLa
1) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.21 Pain Relevance 0
These results demonstrate that endogenous SMN transcripts can be re-directed by trans-splicing and that SMN levels can be significantly increased by the ASO/trans-splicing strategy in a relevant disease context.


SMN Binding (endogenous) of associated with disease
2) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.31 Pain Relevance 0
-actin) and between experiments SMN levels is normalized to GM3813 values (triplicate mean set to 1).
SMN Binding (normalized) of
3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox