INT248470

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.32
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ighmbp2) nucleus (Ighmbp2) DNA binding (Ighmbp2)
transcription factor binding (Ighmbp2) cytoplasm (Ighmbp2)
Anatomy Link Frequency
smooth muscle 1
fibroblasts 1
Ighmbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 26 100.00 Very High Very High Very High
diclofenac 17 87.52 High High
Infliximab 20 85.52 High High
cytokine 21 76.68 Quite High
Inflammation 7 76.32 Quite High
cva 4 72.28 Quite High
Spinal cord 12 72.24 Quite High
fibrosis 4 68.20 Quite High
abdominal pain 2 60.36 Quite High
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 96 100.00 Very High Very High Very High
Cancer 82 97.92 Very High Very High Very High
Aging 3 96.28 Very High Very High Very High
Metastasis 6 90.24 High High
Malignant Neoplastic Disease 22 88.40 High High
Fever 2 87.04 High High
Gastrointestinal Stromal Tumor 46 78.20 Quite High
Necrosis 8 77.28 Quite High
INFLAMMATION 7 76.32 Quite High
Contracture 10 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two cases coexpressed SMA (Fig. 1), strongly but focally.
Gene_expression (coexpressed) of SMA
1) Confidence 0.75 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.07 Pain Relevance 0.04
All antigens used here including c-Kit, CD34, vimentin, smooth muscle actin (SMA), desmin, S100 protein, synaptophysin, CD56 and Ki67 (MIB-1) were summarized in Table 2.
Gene_expression (used) of SMA in smooth muscle
2) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.83 Pain Relevance 0.06
-SMA and COX2 protein expressions were evaluated by immunofluorescence staining and Western blot analysis.


Gene_expression (expressions) of SMA associated with cox2
3) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875629 Disease Relevance 0.66 Pain Relevance 0.52
Future studies could examine the role of expression of the virus vectors and the SMA CNS.
Spec (examine) Gene_expression (expression) of SMA associated with spinal muscular atrophy
4) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.28 Pain Relevance 0
SMA patient fibroblasts (GM3813) were transfected with Lipofectamine™2000 with LiCl (5M) centrifuge purified plasmid in serum free DMEM?
Gene_expression (transfected) of SMA in fibroblasts associated with spinal muscular atrophy
5) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.10 Pain Relevance 0
The SMA murine model expresses the genomic human SMN2 gene and the human SMN?
Gene_expression (expresses) of SMA associated with spinal muscular atrophy
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.39 Pain Relevance 0.06

General Comments

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