INT248477

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.17
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Anatomy Link Frequency
fibroblasts 2
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 20 84.80 Quite High
fibrosis 5 36.20 Quite Low
Intracerebroventricular 10 35.68 Quite Low
Central nervous system 10 26.96 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 160 99.72 Very High Very High Very High
Targeted Disruption 5 98.96 Very High Very High Very High
Disease 30 78.40 Quite High
Death 5 65.44 Quite High
Neurodegenerative Disease 5 60.64 Quite High
Frailty 5 41.44 Quite Low
Epidermolysis Bullosa Simplex 5 40.48 Quite Low
Coagulation Disorder 5 38.16 Quite Low
Immunodeficiency 5 37.68 Quite Low
Cystic Fibrosis 5 36.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SMN levels in the co-transfected cells were comparable to SMN levels detected in the unaffected control fibroblasts, 3814 cells.
Regulation (comparable) of Gene_expression (levels) of SMN in fibroblasts
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.31 Pain Relevance 0
The SMA murine model expresses the genomic human SMN2 gene and the human SMN?
Regulation (genomic) of Gene_expression (expresses) of SMN2 associated with spinal muscular atrophy
2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.39 Pain Relevance 0.07
The SMA murine model expresses the genomic human SMN2 gene and the human SMN?
Regulation (genomic) of Gene_expression (gene) of SMN associated with spinal muscular atrophy
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.39 Pain Relevance 0.07
In contrast, the parental vector that lacked the ASO, pM13, did not result in significant levels of SMN induction (Figure 7C, 7D).
Neg (not) Regulation (result) of Gene_expression (induction) of SMN
4) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.47 Pain Relevance 0.11
ASOs have also been shown to modulate SMN2 expression in vivo in an unaffected transgenic mouse expressing the human SMN2 gene [18].
Neg (unaffected) Regulation (modulate) of Gene_expression (expression) of SMN2 associated with targeted disruption
5) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.61 Pain Relevance 0

General Comments

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