INT248478

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 11.44 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 32 90.12 High High
Disease 6 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Immunodeficiency 1 5.00 Very Low Very Low Very Low
Epidermolysis Bullosa Simplex 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Cystic Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the competition between SMN2 cis-splicing and trans-splicing is likely reduced, providing a potential advantage to trans-splicing in the SMN context compared to other alternatively regulated exons that retain fully functional splice sites.
Negative_regulation (reduced) of Gene_expression (cis-splicing) of SMN2
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.14 Pain Relevance 0

General Comments

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