INT248480

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Anatomy Link Frequency
fibroblasts 1
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 80.92 Quite High
Spinal Muscular Atrophy 64 78.12 Quite High
Coagulation Disorder 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Immunodeficiency 2 5.00 Very Low Very Low Very Low
Epidermolysis Bullosa Simplex 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Cystic Fibrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SMN levels in the co-transfected cells were comparable to SMN levels detected in the unaffected control fibroblasts, 3814 cells.
Regulation (comparable) of SMN in fibroblasts
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.30 Pain Relevance 0
This single vector platform allows for the production of two individual RNAs that target distinct aspects of SMN pre-mRNA, leading to enhanced full-length SMN expression (Figure 1A).
Regulation (target) of SMN
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.08 Pain Relevance 0

General Comments

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