INT248482

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 95.24 Very High Very High Very High
Spinal Muscular Atrophy 96 73.04 Quite High
Coagulation Disorder 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Immunodeficiency 3 5.00 Very Low Very Low Very Low
Epidermolysis Bullosa Simplex 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Cystic Fibrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that endogenous SMN transcripts can be re-directed by trans-splicing and that SMN levels can be significantly increased by the ASO/trans-splicing strategy in a relevant disease context.


Localization (directed) of SMN associated with disease
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.31 Pain Relevance 0
Therefore, a single vector was constructed that was combined the molecular constituents of pM13 and pIn711 by subcloning the SMN trans-splicing cassette into the pIn711 plasmid backbone.
Localization (cassette) of SMN
2) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.19 Pain Relevance 0
1000 dilution of mouse anti-SMN (BD Biosciences) and were produced using 1?
Localization (dilution) of anti-SMN
3) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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