INT248540

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.95
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata4) DNA binding (Gata4) transcription factor binding (Gata4)
cell-cell signaling (Gata4)
Anatomy Link Frequency
cardiogenic 2
myocyte 1
P19 1
Gata4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 32 60.00 Quite High
Potency 2 36.24 Quite Low
imagery 46 5.00 Very Low Very Low Very Low
Action potential 22 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 46 99.44 Very High Very High Very High
Teratoma 20 83.60 Quite High
Death 8 79.92 Quite High
Hyperplasia 2 73.24 Quite High
Natriuresis 6 61.48 Quite High
Myocardial Infarction 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 8 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of EC P19 cells to OT and OT-GKR increased GATA-4 mRNA (Fig. 6A), the transcription factor involved in cardiac development, and Mef2c mRNA (Fig. 6B), the gene involved in cardiac morphogenesis and myogenesis.
Positive_regulation (increased) of GATA-4 mRNA in P19 associated with embryonal carcinoma
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.28 Pain Relevance 0.03
We established that the OTR-nitric oxide-cGMP pathway is essential for the OT-elicited differentiation of P19 stem cells into CM in association with elevation of transcription factors GATA-4 and myocyte-specific enhancer factor 2c (Mef2c) [12].
Positive_regulation (elevation) of GATA-4 in myocyte
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.34 Pain Relevance 0
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Spec (clear) Positive_regulation (induction) of GATA4 in cardiogenic
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Positive_regulation (activation) of GATA4 in cardiogenic
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0

General Comments

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