INT248557

Context Info Confidence 0.38 First Reported 2008 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.28 Pain Relevance 0.12

cytosol (Pou5f1) nucleoplasm (Pou5f1) nucleus (Pou5f1) DNA binding (Pou5f1) transcription factor binding (Pou5f1) cytoplasm (Pou5f1)

Anatomy Link Frequency brains 2 stem cell 2 Pou5f1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 3 85.76 imagery 21 77.40 Action potential 25 21.12 Central nervous system 8 5.00 neurotrophin 3 8 5.00 isoflurane 6 5.00 anesthesia 5 5.00 Thoracotomy 3 5.00 Inflammatory response 2 5.00 Morphine 2 5.00

Disease Link Frequency Relevance Heat Cancer 6 96.32 Teratoma 18 92.48 Infection 49 88.72 Cytomegalovirus Infection 56 88.32 Coronary Artery Disease 1 85.76 Viral Infection 13 81.36 Neurodegenerative Disease 6 63.36 Injury 30 32.08 Myocardial Infarction 32 31.80 Cicatrix 17 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Data obtained from these experiments demonstrated that Oct4 expression was reduced in cells obtained from virus-infected brains compared to the cells from the brains of uninfected animals (upper panel, histogram overlays).

Negative_regulation (reduced) of Gene_expression (expression) of Oct4 in brains

1) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.49 Pain Relevance 0

In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)

Negative_regulation (levels) of Gene_expression (expression) of Pou5f1

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0

We have previously demonstrated that no expression of Nanog or Pou5f1 was detected following Nkx2-5(+) CPC derivation and extended culture in vitro.

Negative_regulation (detected) of Neg (no) Gene_expression (expression) of Pou5f1

3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.37 Pain Relevance 0

Expression of stem cell markers (Oct4, NANOG, Rex1) decreased substantially by day 28, while early stage cardiac transcriptional factors (Nkx2.5, MEF2C) appeared between days 14–28.

Negative_regulation (decreased) of Gene_expression (Expression) of Oct4 in stem cell

4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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