INT248557

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.28
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pou5f1) nucleoplasm (Pou5f1) nucleus (Pou5f1)
DNA binding (Pou5f1) transcription factor binding (Pou5f1) cytoplasm (Pou5f1)
Anatomy Link Frequency
brains 2
stem cell 2
Pou5f1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 3 85.76 High High
imagery 21 77.40 Quite High
Action potential 25 21.12 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
neurotrophin 3 8 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 96.32 Very High Very High Very High
Teratoma 18 92.48 High High
Infection 49 88.72 High High
Cytomegalovirus Infection 56 88.32 High High
Coronary Artery Disease 1 85.76 High High
Viral Infection 13 81.36 Quite High
Neurodegenerative Disease 6 63.36 Quite High
Injury 30 32.08 Quite Low
Myocardial Infarction 32 31.80 Quite Low
Cicatrix 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data obtained from these experiments demonstrated that Oct4 expression was reduced in cells obtained from virus-infected brains compared to the cells from the brains of uninfected animals (upper panel, histogram overlays).


Negative_regulation (reduced) of Gene_expression (expression) of Oct4 in brains
1) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.49 Pain Relevance 0
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Negative_regulation (levels) of Gene_expression (expression) of Pou5f1
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
We have previously demonstrated that no expression of Nanog or Pou5f1 was detected following Nkx2-5(+) CPC derivation and extended culture in vitro.
Negative_regulation (detected) of Neg (no) Gene_expression (expression) of Pou5f1
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.37 Pain Relevance 0
Expression of stem cell markers (Oct4, NANOG, Rex1) decreased substantially by day 28, while early stage cardiac transcriptional factors (Nkx2.5, MEF2C) appeared between days 14–28.
Negative_regulation (decreased) of Gene_expression (Expression) of Oct4 in stem cell
4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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