INT24857

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.70
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hippocampus 2
spinal 1
spinal cord 1
astrocytes 1
Slc12a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 21 98.80 Very High Very High Very High
lidocaine 9 97.32 Very High Very High Very High
Serotonin 18 95.72 Very High Very High Very High
antagonist 6 95.04 Very High Very High Very High
Raphe 6 94.16 High High
tetrodotoxin 10 93.28 High High
nMDA receptor 9 93.16 High High
sodium channel 3 86.56 High High
Action potential 2 81.40 Quite High
ischemia 1 60.84 Quite High
Disease Link Frequency Relevance Heat
Injury 4 91.96 High High
Hypoxia 4 83.92 Quite High
Cv Unclassified Under Development 1 60.84 Quite High
Ganglion Cysts 15 53.52 Quite High
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Natriuresis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KCC3a isoform was localized to astrocytes.
Localization (localized) of KCC3a in astrocytes
1) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.64 Pain Relevance 0.61
The authors also examined the effect of clonidine on KCl evoked acetylcholine release using perfusion of spinal cord slices, in which some spinal circuitry is maintained.
Localization (release) of KCl in spinal
2) Confidence 0.46 Published 2005 Journal Anesthesiology Section Body Doc Link 15731607 Disease Relevance 0 Pain Relevance 0
Similarly, in spinal cord slices, clonidine enhanced KCl evoked acetylcholine release in tissue from SNL animals but inhibited such release in tissue from normal animals.
Localization (release) of KCl in spinal cord
3) Confidence 0.46 Published 2005 Journal Anesthesiology Section Body Doc Link 15731607 Disease Relevance 0 Pain Relevance 0
Both KCl- and p-chloroamphetamine-induced release had recovered in the grafted hippocampus and the responses were even greater than those seen in normal animals.
Localization (release) of KCl in hippocampus associated with hippocampus
4) Confidence 0.32 Published 1989 Journal Brain Res. Section Abstract Doc Link 2477113 Disease Relevance 0 Pain Relevance 0.70
Two weeks after 5,7-DHT lesion, baseline 5-HT release was reduced to levels below detection, and KCl- and p-chloro-amphetamine-evoked release was reduced by 90-95%.
Localization (release) of KCl
5) Confidence 0.32 Published 1989 Journal Brain Res. Section Abstract Doc Link 2477113 Disease Relevance 0 Pain Relevance 0.38
In the chronically denervated hippocampus (3 months after lesion), baseline 5-HT release had recovered to near-normal levels, but KCl- and p-chloroamphetamine-evoked release remained severely impaired.
Localization (release) of KCl in hippocampus associated with hippocampus
6) Confidence 0.28 Published 1989 Journal Brain Res. Section Abstract Doc Link 2477113 Disease Relevance 0 Pain Relevance 0.44
KCl-evoked release of [3H]acetylcholine was inhibited by 1.2 mM MgCl2 and 100 microM lidocaine.
Localization (release) of KCl associated with lidocaine
7) Confidence 0.21 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2842697 Disease Relevance 0 Pain Relevance 0.41
KCl-, NMDA-, and glycine-evoked release of [3H]acetylcholine was studied in superfused rat striatal slices.
Localization (release) of KCl
8) Confidence 0.19 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2842697 Disease Relevance 0 Pain Relevance 0.38
Glycine-evoked release was calcium-dependent and was inhibited by 0.1 microM strychnine whereas KCl- and NMDA-evoked release were resistant to strychnine.
Localization (release) of KCl
9) Confidence 0.19 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2842697 Disease Relevance 0 Pain Relevance 0.49
PMA-stimulated secretion persisted for the duration of the experiment, while KCl-stimulated secretion occurred primarily within 5 minutes and was completed by 15 minutes.
Localization (secretion) of KCl
10) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2838897 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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