INT24860

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.13
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1D) histone binding (CD1D) plasma membrane (CD1D)
cytoplasm (CD1D)
Anatomy Link Frequency
mast cell 2
lymph node 1
CD1D (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 99.08 Very High Very High Very High
Inflammation 15 93.28 High High
chemokine 3 91.48 High High
abdominal pain 1 82.12 Quite High
cINOD 2 79.76 Quite High
dexamethasone 6 77.12 Quite High
Pain 1 72.20 Quite High
nociceptor 1 25.00 Low Low
Catecholamine 16 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 2 100.00 Very High Very High Very High
Interdigitating Dendritic Cell Sarcoma 7 98.14 Very High Very High Very High
Hypersensitivity 5 96.00 Very High Very High Very High
INFLAMMATION 17 93.28 High High
Anaphylaxis 1 92.20 High High
Lymphadenopathy 1 88.00 High High
Cancer 5 83.96 Quite High
Abdominal Pain 1 82.12 Quite High
Malignant Neoplastic Disease 3 75.00 Quite High
Lymphatic System Cancer 1 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphologic and cytochemical analysis of biopsies from the abdominal mass and inguinal node were consistent with a diagnosis of IDCS, and immunohistochemical stains of the lymph node were positive for CLA, Kp-1, S-100, while negative for CD1a, CD3, CD20, CKER, and HMB45.
Positive_regulation (negative) of CD1a in lymph node associated with interdigitating dendritic cell sarcoma
1) Confidence 0.49 Published 2002 Journal Leuk. Lymphoma Section Abstract Doc Link 12153170 Disease Relevance 1.16 Pain Relevance 0.08
This result suggests that the R3 component is induced by the activation of a different population of peripheral afferents from the R2 component.
Positive_regulation (induced) of R3
2) Confidence 0.41 Published 1989 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2477219 Disease Relevance 0 Pain Relevance 0
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of HMC-1
3) Confidence 0.04 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
In addition, BCE inhibited the IL-4, IL-5 and TNF-alpha mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1.
Positive_regulation (induction) of HMC-1 in mast cells associated with leukemia
4) Confidence 0.03 Published 2004 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 15209365 Disease Relevance 0.67 Pain Relevance 0.15
To demonstrate the effect of intracellular Ca(2+) on IL-8 production and related signaling, we stimulated human mast cell line HMC-1 with either calcium ionophore A23187 or thapsigargin.
Positive_regulation (stimulated) of HMC-1 in mast cell
5) Confidence 0.02 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.14 Pain Relevance 0.14
-induced HMC-1
Positive_regulation (induced) of HMC-1
6) Confidence 0.01 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.26

General Comments

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