INT24863

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.85
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC12A2) plasma membrane (SLC12A2) transmembrane transport (SLC12A2)
Anatomy Link Frequency
horizontal cells 1
lens 1
ciliary 1
SLC12A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 3 99.16 Very High Very High Very High
agonist 9 98.76 Very High Very High Very High
antagonist 9 96.92 Very High Very High Very High
potassium channel 84 95.68 Very High Very High Very High
Catecholamine 3 84.48 Quite High
Glutamate receptor 12 75.80 Quite High
tetrodotoxin 18 66.40 Quite High
Morphine 4 50.00 Quite Low
cytokine 2 50.00 Quite Low
pruritus 3 28.08 Quite Low
Disease Link Frequency Relevance Heat
Cancer 23 100.00 Very High Very High Very High
Myopia 132 97.76 Very High Very High Very High
Ganglion Cysts 18 93.36 High High
Colon Cancer 53 77.44 Quite High
Disease 27 74.72 Quite High
Hypersensitivity 5 68.80 Quite High
Hypomagnesemia 4 66.68 Quite High
Diarrhoea 5 65.56 Quite High
Toxicity 10 64.84 Quite High
Disease Progression 7 58.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bumetanide, as a selective NKCC1 inhibitor, would be expected to affect the ciliary secretion of Na, K, and Cl ions [36], as well as the targeted apical membrane of the RPE and ON bipolar dendrites.
Negative_regulation (inhibitor) of NKCC1 in ciliary
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.17 Pain Relevance 0
Thus, it is unlikely that the effects of blocking the NKCC1 on negative lens defocus, i.e. of inhibiting the development of myopia, are due to any major compromise of outer retinal function.
Negative_regulation (blocking) of NKCC1 in lens associated with myopia
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.15 Pain Relevance 0.07
for the second chloride binding site and thus inhibit NKCC1 function [23].
Negative_regulation (inhibit) of NKCC1
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.10 Pain Relevance 0.06
Thus, bumetanide, which is a selective blocker of NKCC1 may also alter retinal function by blocking the cation-chloride uptake at the ON-bipolar dendrites (and horizontal cells).
Negative_regulation (blocker) of NKCC1 in horizontal cells
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.25 Pain Relevance 0.10
Loop diuretics, by comparison, act to inhibit the cation-chloride NKCC cotransporter, thus inhibiting the coordinated trans-membrane movement of Na, K and Cl ions [23].
Negative_regulation (inhibit) of NKCC
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.25 Pain Relevance 0.25
The similarities between the biometric effects of NKCC inhibition and biometric reports of the blockade of the retinal ON response, suggest a possible common mechanism.
Negative_regulation (inhibition) of NKCC
6) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2481396 Disease Relevance 0 Pain Relevance 0.03
In both types of effector cells, adrenaline significantly suppressed NKCC at a final concentration of 10(-11) M.
Negative_regulation (suppressed) of NKCC
7) Confidence 0.27 Published 1989 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2477332 Disease Relevance 0 Pain Relevance 0.35
Adrenaline-induced NKCC suppression was completely and potently antagonized by the mixed beta 1/beta 2-receptor antagonist propranolol and the selective beta 2-receptor antagonist ICI 118,551 but not by the beta 1-selective antagonist metoprolol.
Negative_regulation (suppression) of NKCC associated with antagonist
8) Confidence 0.27 Published 1989 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2477332 Disease Relevance 0 Pain Relevance 0.43
Pretreatment of LD effector cells with IFN-alpha reduced the NKCC suppression by subsequent adrenaline treatment.
Negative_regulation (suppression) of NKCC
9) Confidence 0.23 Published 1989 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 2477332 Disease Relevance 0 Pain Relevance 0.33
RESULTS: Significant suppression of NKCC was observed at 2 and 24 h after the onset of intravenous morphine exposure.
Negative_regulation (suppression) of NKCC
10) Confidence 0.14 Published 1995 Journal Anesthesiology Section Body Doc Link 7661350 Disease Relevance 0 Pain Relevance 0
Suppression of NKCC persisted for 24 h after termination of morphine infusion in a "high"-dose study group. gamma-Interferon-stimulated NKCC and antibody-dependent cell cytotoxicity were also decreased after 24 h of intravenous morphine exposure.
Negative_regulation (Suppression) of NKCC
11) Confidence 0.14 Published 1995 Journal Anesthesiology Section Body Doc Link 7661350 Disease Relevance 0 Pain Relevance 0
Panitumumab showed a 46% decrease in tumor progression rate versus BSC alone (hazard ratio 0.54; 95% CI 0.44, 0.66; P<0.000000001, stratified log-rank test).
Negative_regulation (decrease) of BSC associated with cancer
12) Confidence 0.10 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012427 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox