INT248666

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 91.72 High High
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 89.76 High High
Infection 20 81.04 Quite High
Viral Infection 4 29.20 Quite Low
Adenovirus Infection 14 5.00 Very Low Very Low Very Low
Hepatotoxicity 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that a single dose of recombinant adenovirus significantly suppresses CYP3A2 and 2C11 expression and function in the male Sprague-Dawley rat for 14 days, long after the innate immune response against the virus resolves [9].
Negative_regulation (suppresses) of Gene_expression (expression) of CYP3A2
1) Confidence 0.36 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.20 Pain Relevance 0.05
Administration of helper-dependent adenovirus (HDAd), devoid of all viral genes and significantly less immunogenic than wild type or first generation adenoviruses [17,23], suppressed CYP3A2 protein, activity, and gene expression for 14 days (Figures 1, 2, 3, p ?
Negative_regulation (suppressed) of Gene_expression (expression) of CYP3A2 protein
2) Confidence 0.36 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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