INT248671

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.86 Pain Relevance 0.03

nucleus (Rxrb)

Anatomy Link Frequency nucleus 2 Rxrb (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 3 50.08 Inflammatory mediators 3 5.00 ketamine 3 5.00 anesthesia 3 5.00 Kinase C 3 5.00 Inflammation 3 5.00 Inflammatory stimuli 3 5.00

Disease Link Frequency Relevance Heat Adenovirus Infection 21 98.60 Targeted Disruption 3 96.92 Infection 30 81.36 Viral Infection 6 63.36 Hepatotoxicity 9 50.40 Toxicity 12 28.28 INFLAMMATION 9 5.00 Heart Rate Under Development 6 5.00 Pulmonary Disease 3 5.00 Adverse Drug Reaction 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although no appreciable changes in PXR and RXR mRNA levels were detected after administration of any of the vectors studied, post-translational modifications of these proteins and CYP itself such as phosphorylation, ubiquitination and redistribution between the nucleus and cytoplasm in response to virus-induced cell signaling cascades could account for the observed reduction in CYP during adenovirus infection and would not be readily detectable by the techniques used to assess changes in CYP, RXR and PXR described in this manuscript [30-32].

Neg (no) Regulation (changes) of RXR in nucleus associated with adenovirus infection

1) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.38 Pain Relevance 0

Although no appreciable changes in PXR and RXR mRNA levels were detected after administration of any of the vectors studied, post-translational modifications of these proteins and CYP itself such as phosphorylation, ubiquitination and redistribution between the nucleus and cytoplasm in response to virus-induced cell signaling cascades could account for the observed reduction in CYP during adenovirus infection and would not be readily detectable by the techniques used to assess changes in CYP, RXR and PXR described in this manuscript [30-32].

Regulation (changes) of RXR in nucleus associated with adenovirus infection

2) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.25 Pain Relevance 0

Significant changes in RXR?

Regulation (changes) of RXR

3) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

This test has worked.