INT248671

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxrb)
Anatomy Link Frequency
nucleus 2
Rxrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 50.08 Quite High
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 21 98.60 Very High Very High Very High
Targeted Disruption 3 96.92 Very High Very High Very High
Infection 30 81.36 Quite High
Viral Infection 6 63.36 Quite High
Hepatotoxicity 9 50.40 Quite High
Toxicity 12 28.28 Quite Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no appreciable changes in PXR and RXR mRNA levels were detected after administration of any of the vectors studied, post-translational modifications of these proteins and CYP itself such as phosphorylation, ubiquitination and redistribution between the nucleus and cytoplasm in response to virus-induced cell signaling cascades could account for the observed reduction in CYP during adenovirus infection and would not be readily detectable by the techniques used to assess changes in CYP, RXR and PXR described in this manuscript [30-32].
Neg (no) Regulation (changes) of RXR in nucleus associated with adenovirus infection
1) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.38 Pain Relevance 0
Although no appreciable changes in PXR and RXR mRNA levels were detected after administration of any of the vectors studied, post-translational modifications of these proteins and CYP itself such as phosphorylation, ubiquitination and redistribution between the nucleus and cytoplasm in response to virus-induced cell signaling cascades could account for the observed reduction in CYP during adenovirus infection and would not be readily detectable by the techniques used to assess changes in CYP, RXR and PXR described in this manuscript [30-32].
Regulation (changes) of RXR in nucleus associated with adenovirus infection
2) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.25 Pain Relevance 0
Significant changes in RXR?
Regulation (changes) of RXR
3) Confidence 0.02 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

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