INT248677

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 27
Disease Relevance 4.49
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2) DNA binding (Nr0b2) protein complex (Nr0b2)
transcription factor binding (Nr0b2) cytoplasm (Nr0b2)
Anatomy Link Frequency
hepatocytes 5
bile 4
liver 2
Nr0b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 75 99.52 Very High Very High Very High
Bile 1525 99.20 Very High Very High Very High
Kinase C 2 60.12 Quite High
dexamethasone 50 5.00 Very Low Very Low Very Low
anesthesia 27 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 475 99.36 Very High Very High Very High
Repression 100 98.04 Very High Very High Very High
Adenovirus Infection 14 96.12 Very High Very High Very High
Bordatella Infection 75 93.52 High High
Van Bogaert's Disease 75 88.80 High High
Toxicity 33 33.68 Quite Low
Infection 20 17.12 Low Low
Cytomegalovirus Infection 27 5.00 Very Low Very Low Very Low
Biliary Fistula 25 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (induction) of SHP in bile associated with bile and fistula
1) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.12
In the chronic bile fistula rat model, we observed a rapid induction of SHP mRNA following the intestinal infusion of TCA (Fig. 6).
Positive_regulation (induction) of SHP in bile associated with bile and fistula
2) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.11
Finally, a p38 MAPK and a JNK1/2 inhibitor were also used but failed to inhibit SHP mRNA induction by TCA (data not shown).
Positive_regulation (induction) of SHP
3) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.06 Pain Relevance 0.03
It was also observed that there was about a 30 min lag between the activation of the AKT signaling pathway and induction of SHP.


Positive_regulation (induction) of SHP
4) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.12
The induction of SHP protein may be involved in the long term (>3 h) repression of gluconeogenic genes.
Positive_regulation (induction) of SHP associated with repression
5) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.10 Pain Relevance 0.10
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (induction) of SHP in bile associated with bile and fistula
6) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.23 Pain Relevance 0.11
Activation of the insulin signaling pathway appears to be linked to the upregulation of farnesoid X receptor functional activity and SHP induction.



Positive_regulation (upregulation) of SHP
7) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.07
The data (Fig. 7A) show that Wortmannin significantly blocked the ability of TCA to induce SHP mRNA in primary hepatocytes in the absence of insulin.
Positive_regulation (induce) of SHP in hepatocytes
8) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.13 Pain Relevance 0.07
It has been hypothesized that the downregulation of these genes is through induction of SHP, which has been reported to physically interact with HNF-4?
Positive_regulation (induction) of SHP
9) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.30
In contrast, the AKT inhibitor enhanced the induction of SHP by TCA (Fig. 7B).
Positive_regulation (induction) of SHP
10) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.07 Pain Relevance 0.03
These results suggest that the insulin signaling pathway must be activated to get optimal induction of SHP mRNA by TCA.
Positive_regulation (induction) of SHP
11) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.16 Pain Relevance 0.04
Therefore, the activation of ERK1/2 (Fig. 1) by TCA may help stabilize SHP protein.
Positive_regulation (stabilize) of SHP
12) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.09 Pain Relevance 0.09
Moreover, the inhibition of AKT by a specific chemical inhibitor failed to inhibit SHP induction by TCA (Fig. 7B).
Positive_regulation (induction) of SHP
13) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.14 Pain Relevance 0.04
The induction of SHP mRNA in PRH was strongly blocked by inhibition of PI3 kinase or PKC?
Positive_regulation (induction) of SHP
14) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.31 Pain Relevance 0.10
Activation of the insulin signaling pathway inhibits induction of SHP by the FXR agonist GW4064
Positive_regulation (induction) of SHP associated with agonist
15) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0 Pain Relevance 0.09
There was no significant inhibition of SHP induction when specific chemical inhibitors of the ERK1/2 (Fig. 7C) or p38 MAPK (data not shown) were added to primary hepatocytes in culture.
Positive_regulation (induction) of SHP in hepatocytes
16) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.16 Pain Relevance 0.04
regulates FXR and SHP induction.
Positive_regulation (induction) of SHP
17) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.17 Pain Relevance 0
Activation of the insulin signaling pathway appears to be linked to the upregulation of farnesoid X receptor functional activity and SHP induction.



Positive_regulation (induction) of SHP
18) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.06
However, in primary rat hepatocytes, we did not observe any significant inhibition of SHP mRNA induction by TCA when the Ca2+-dependent PKC isozyme inhibitor Gö6976 was used at concentrations reported to inhibit FXR-dependent induction in other cells (45)(Fig. 8D).
Positive_regulation (induction) of SHP in hepatocytes
19) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.12 Pain Relevance 0
mRNA and protein (see supplementary Fig II) using a recombinant lentivirus also significantly blocked the ability of TCA to induce SHP mRNA (Fig. 8B) and a second FXR target gene ABCB11 (Fig. 8C).
Positive_regulation (induce) of SHP
20) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox