INT248678

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Rela) DNA binding (Rela) protein complex (Rela)
response to stress (Rela) cytoplasm (Rela) cytosol (Rela)
Anatomy Link Frequency
macrophage 1
adipose tissue 1
Rela (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 47 97.40 Very High Very High Very High
fibrosis 44 96.52 Very High Very High Very High
Inflammation 55 90.24 High High
chemokine 2 85.84 High High
withdrawal 10 60.08 Quite High
Kinase C 1 53.92 Quite High
ischemia 26 50.80 Quite High
antagonist 8 50.24 Quite High
Brush evoked pain 6 50.00 Quite Low
reflex sympathetic dystrophy 11 43.12 Quite Low
Disease Link Frequency Relevance Heat
Obesity 40 99.12 Very High Very High Very High
Ureteral Obstruction 45 98.82 Very High Very High Very High
Apoptosis 5 97.60 Very High Very High Very High
Fibrosis 54 96.52 Very High Very High Very High
INFLAMMATION 68 90.24 High High
Cv Unclassified Under Development 28 88.04 High High
Infection 10 83.96 Quite High
Disorder Of Lipid Metabolism 3 83.92 Quite High
Adhesions 2 82.72 Quite High
Chronic Renal Failure 6 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FJPMH conceived the NFkB experiments along with MdM and TJC.
Gene_expression (experiments) of NFkB
1) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584041 Disease Relevance 0.18 Pain Relevance 0.21
Expression of genes associated with the PI3K, PKC and nuclear factor kappa B (NFKB) pathways were induced with respect to those found in saline treated animals on average by a factor of 3.8, 4 and 4.6 respectively by each of the viruses included in this study.
Gene_expression (Expression) of NFKB
2) Confidence 0.08 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.08 Pain Relevance 0.03
In UUO, there is activation of the renin┬ľangiotensin system with production of reactive oxygen species (ROS) and NFkB, which promote macrophage infiltration [37], renal tubular apoptosis and interstitial fibrosis [38].
Gene_expression (production) of NFkB in macrophage associated with fibrosis, ureteral obstruction and apoptosis
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 1.44 Pain Relevance 0.33
and IL-10) levels and Toll Like Receptor 4 (TLR4), Nuclear Factor kBp65 (NF-kBp65), Hormone Sensitive Lipase (HSL) and, Perilipin protein expression were assessed in the adipose tissue.
Gene_expression (expression) of Nuclear Factor kBp65 in adipose tissue associated with obesity
4) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2959201 Disease Relevance 0.64 Pain Relevance 0.33

General Comments

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