INT24868

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.08
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus 2
B cells 1
cleavage 1
lungs 1
nervous system 1
Ighd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 99.08 Very High Very High Very High
Multiple sclerosis 29 97.32 Very High Very High Very High
Clonidine 3 90.96 High High
cytokine 42 90.52 High High
headache 1 79.76 Quite High
intrathecal 2 75.00 Quite High
Central nervous system 22 62.96 Quite High
Inflammatory mediators 3 49.52 Quite Low
chemokine 5 47.60 Quite Low
Inflammatory response 7 39.68 Quite Low
Disease Link Frequency Relevance Heat
Neurological Disease 3 99.56 Very High Very High Very High
INFLAMMATION 64 99.08 Very High Very High Very High
Demyelinating Disease 34 97.32 Very High Very High Very High
Infection 122 87.80 High High
Headache 1 79.76 Quite High
Growth Problems 1 75.00 Quite High
Toxicity 6 69.40 Quite High
Retroviridae Infections 1 66.56 Quite High
Drug Induced Neurotoxicity 3 65.28 Quite High
Alzheimer's Dementia 61 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another type of reverse signaling though tmTNF is possible; after release of solTNF by TACE, the TNF intracellular domain (TNF-ICD) can be released into the cell through regulated intramembrane proteolysis by signal peptide peptidase-like proteases where it is trafficked to the nucleus by virtue of a nuclear localization signal resulting in increased production of pro-inflammatory cytokines [49-51].
Localization (released) of ICD in nucleus associated with inflammation and cytokine
1) Confidence 0.78 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.22 Pain Relevance 0.16
The LRP-ICD has been shown to translocate to the nucleus and interact with Fe65 and Tip60, although whether this occurs under physiological conditions remains to be determined.
Localization (translocate) of ICD in nucleus
2) Confidence 0.73 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.30 Pain Relevance 0.12
-secretase LRP cleavage and release of the LRP-ICD.
Localization (release) of ICD in cleavage
3) Confidence 0.68 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.24 Pain Relevance 0.05
The total number of B cells and the frequency of IgD and PNAhi CD19+ B cells were slightly lower in the lungs of I?
Localization (frequency) of IgD in lungs
4) Confidence 0.50 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0 Pain Relevance 0
Among control patients with other inflammatory nervous system diseases, ITP of IgA, IgM and IgD was found more frequently, and of IgG in a smaller percentage compared with MS patients.
Localization (found) of IgD in nervous system associated with multiple sclerosis, neurological disease and inflammation
5) Confidence 0.11 Published 1989 Journal Acta Neurol. Scand. Section Abstract Doc Link 2801020 Disease Relevance 1.08 Pain Relevance 0.60
At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?
Localization (were) of surface IgD in B cells
6) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
We have evaluated the effect of galanin (Gal), a newly identified hypothalamic peptide, on growth hormone (GH) secretion in 10 children with normal stature (NS), nine with constitutional growth delay (CGD), and five with isolated GH deficiency (IGHD).
Localization (secretion) of IGHD
7) Confidence 0.07 Published 1989 Journal Pediatr. Res. Section Abstract Doc Link 2477790 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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