INT248682

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.41
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxrb)
Anatomy Link Frequency
liver 1
fibroblasts 1
internal 1
Rxrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 43 96.60 Very High Very High Very High
agonist 198 90.48 High High
rheumatoid arthritis 54 81.84 Quite High
Kinase C 4 78.00 Quite High
Arthritis 33 61.00 Quite High
Potency 18 45.20 Quite Low
cytokine 37 44.40 Quite Low
Inflammatory stimuli 10 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 28 100.00 Very High Very High Very High
Toxicity 23 98.08 Very High Very High Very High
INFLAMMATION 60 96.60 Very High Very High Very High
Necrosis 7 91.36 High High
Cancer 10 91.00 High High
Stress 13 88.24 High High
Rheumatoid Arthritis 57 81.84 Quite High
Infection 40 69.20 Quite High
Arthritis 24 61.00 Quite High
Experimental Arthritis 18 56.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MKo contributed to the study of RAR or RXR subtype expression and statistical analysis.
Gene_expression (expression) of RXR
1) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.72 Pain Relevance 0.25
on the expression of RAR and RXR subtypes
Gene_expression (expression) of RXR
2) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.06 Pain Relevance 0.04
Synovial fibroblasts expressed all RAR and RXR subtypes except RXR-?.
Gene_expression (expressed) of RXR in fibroblasts
3) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.15 Pain Relevance 0.25
A number of xenobiotic metabolism related receptors of interest were present on the array but were either not differentially expressed (pregnane X receptor, Nr1i2; constitutive androstane receptor, Nr1i3; aryl hydrocarbon receptor, Ahr; peroxisome proliferator-activated receptor alpha and gamma, Ppara/Pparg; retinoid x receptor alpha and beta, Rxra/Rxrb) or minimally passed threshold criteria for differential expression (retinoid X receptor, Rxrg).
Gene_expression (expression) of retinoid X receptor
4) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
These pathways are of particular interest in the context of explaining our findings with respect to PXR and RXR expression.
Gene_expression (expression) of RXR
5) Confidence 0.07 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.21 Pain Relevance 0.04
l of QuantumRNA™ 18S internal standard (Ambion, Austin, TX) at a primer:competimer ratio of 4:6 for CYP 3A2 and 2C11 and 3:7 for PXR and RXR reactions.
Gene_expression (reactions) of RXR in internal
6) Confidence 0.06 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0 Pain Relevance 0
Additional studies assessing the level of SHP in the liver during adenovirus infection, distribution patterns and phosphorylation status of PXR and RXR?
Gene_expression (infection) of RXR in liver associated with adenovirus infection
7) Confidence 0.06 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.18 Pain Relevance 0
Expression patterns of the pregnane × receptor (PXR) and the retinoid × receptor alpha (RXR?)
Gene_expression (Expression) of RXR
8) Confidence 0.05 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.10 Pain Relevance 0

General Comments

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