INT248684

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.26
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2) DNA binding (Nr0b2) protein complex (Nr0b2)
transcription factor binding (Nr0b2) cytoplasm (Nr0b2)
Anatomy Link Frequency
liver 2
hepatocytes 1
Nr0b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 122 79.64 Quite High
Kinase C 3 60.12 Quite High
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 21 99.16 Very High Very High Very High
Bordatella Infection 6 93.00 High High
Fistula 38 79.96 Quite High
Repression 8 76.80 Quite High
Infection 30 17.12 Low Low
Toxicity 14 5.00 Very Low Very Low Very Low
Hepatotoxicity 9 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low
Van Bogaert's Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of SHP mRNA in PRH was strongly blocked by inhibition of PI3 kinase or PKC?
Gene_expression (mRNA) of SHP
1) Confidence 0.41 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.30 Pain Relevance 0.10
There was no significant inhibition of SHP induction when specific chemical inhibitors of the ERK1/2 (Fig. 7C) or p38 MAPK (data not shown) were added to primary hepatocytes in culture.
Gene_expression (induction) of SHP in hepatocytes
2) Confidence 0.41 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.16 Pain Relevance 0.04
To date an increase in SHP expression during adenovirus expression has not been described.
Gene_expression (expression) of SHP
3) Confidence 0.15 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.28 Pain Relevance 0
The small heterodimer partner (SHP), an orphan nuclear receptor specifically expressed in the liver and a limited number of other tissues, is a transcriptional co-activator of NFKB and is also activated by JNK [44,45].
Gene_expression (expressed) of SHP in liver
4) Confidence 0.13 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.29 Pain Relevance 0.03
Additional studies assessing the level of SHP in the liver during adenovirus infection, distribution patterns and phosphorylation status of PXR and RXR?
Gene_expression (level) of SHP in liver associated with adenovirus infection
5) Confidence 0.13 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.23 Pain Relevance 0

General Comments

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