INT24871

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.87
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 4
body 2
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Mexiletine 1 99.92 Very High Very High Very High
Morphine 16 99.76 Very High Very High Very High
methadone 2 99.68 Very High Very High Very High
Codeine 8 99.56 Very High Very High Very High
Paracetamol 2 99.32 Very High Very High Very High
Buprenorphine 2 99.28 Very High Very High Very High
corticosteroid 19 96.96 Very High Very High Very High
Inflammation 7 70.88 Quite High
cytokine 21 56.12 Quite High
headache 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Wheal 8 96.52 Very High Very High Very High
Hypersensitivity 52 95.16 Very High Very High Very High
Asthma 139 94.64 High High
Anaphylaxis 8 91.20 High High
Chronic Sinusitis 71 86.96 High High
Drug Hypersensitivity 1 83.16 Quite High
INFLAMMATION 11 70.88 Quite High
Repression 1 59.20 Quite High
Occupational Lung Diseases 2 51.72 Quite High
Rhinitis 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hapten inhibition studies with morphine and a number of structurally-related analogues revealed that morphine and codeine were the most potent inhibitors of IgE binding to a morphine-solid phase.
Negative_regulation (inhibitors) of IgE Binding (binding) of associated with codeine and morphine
1) Confidence 0.58 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2478047 Disease Relevance 0.17 Pain Relevance 1.04
Nalorphine, meperidine, and methadone were also good inhibitors of IgE binding, but naltrexone, buprenorphine, and fentanyl proved to be poor inhibitors.
Negative_regulation (inhibitors) of IgE Binding (binding) of associated with methadone and buprenorphine
2) Confidence 0.58 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2478047 Disease Relevance 0.16 Pain Relevance 1.04
After studying control samples, where equal volumes of PBS were preincubated instead of inhibitors, the inhibition of the specific IgE binding was expressed as: 100- (absorbance of samples preincubated with allergens/absorbance of samples preincubated with PBS) ×100 (%).


Negative_regulation (inhibition) of IgE Binding (binding) of
3) Confidence 0.51 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526437 Disease Relevance 0.05 Pain Relevance 0
Inhibition of IgE binding by monoethylene-glycol showed that the cross-reactivity was due to hydrophobic binding of IgE to the drug.
Negative_regulation (Inhibition) of IgE Binding (binding) of
4) Confidence 0.47 Published 1995 Journal Mol. Immunol. Section Abstract Doc Link 7723771 Disease Relevance 0.26 Pain Relevance 0.24
It selectively binds to circulating immunoglobulin E (IgE) and, thereby, prevents binding of IgE to mast cells and other effector cells.
Negative_regulation (prevents) of IgE Binding (binding) of in mast cells
5) Confidence 0.40 Published 2004 Journal BioDrugs Section Abstract Doc Link 15571425 Disease Relevance 0.41 Pain Relevance 0.13
It selectively binds to circulating immunoglobulin E (IgE) and, thereby, prevents binding of IgE to mast cells and other effector cells.
Negative_regulation (prevents) of IgE Binding (binding) of in mast cells
6) Confidence 0.40 Published 2004 Journal Treat Respir Med Section Abstract Doc Link 15219177 Disease Relevance 0.41 Pain Relevance 0.13
Actually, a recent report describes reduced IgE binding of the major shrimp allergen Pen a 1 (tropomyosin) in parallel with the gradual conversion to vertebrate tropomyosins by targeted substitution of key amino acid positions (48).
Negative_regulation (reduced) of IgE Binding (binding) of
7) Confidence 0.32 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1540723 Disease Relevance 0.10 Pain Relevance 0
The assay was PP-specific because only PP, but no other pyrazolone derivative (antipyrine, aminophenazone, or metamizol), was able to inhibit IgE-binding in the system.
Negative_regulation (inhibit) of IgE Binding (binding) of
8) Confidence 0.28 Published 2003 Journal J. Allergy Clin. Immunol. Section Body Doc Link 12704373 Disease Relevance 0 Pain Relevance 0
The mechanism is a combination of altered regulation of IgE syntheses and induction of IgE-blocking antibodies, with the capacity to competitively inhibit the interaction between allergen and IgE.
Negative_regulation (inhibit) of IgE Binding (interaction) of
9) Confidence 0.16 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643106 Disease Relevance 0 Pain Relevance 0
The results implicate a decrease in the amount of antigen specific IgE molecules binding on the surface of mast cells in the body.
Negative_regulation (decrease) of IgE Binding (binding) of in body
10) Confidence 0.04 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 1.31 Pain Relevance 0.06

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