INT24873

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Context Info
Confidence 0.07
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.73
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (KLF1) intracellular (KLF1) DNA binding (KLF1)
Anatomy Link Frequency
lymphocytes 1
T cells 1
ovary 1
KLF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 13 99.90 Very High Very High Very High
Infliximab 20 99.60 Very High Very High Very High
tetrodotoxin 2 98.56 Very High Very High Very High
Inflammation 45 98.36 Very High Very High Very High
qutenza 16 96.36 Very High Very High Very High
rheumatoid arthritis 64 94.84 High High
antagonist 10 92.60 High High
psoriasis 68 86.64 High High
Arthritis 9 85.64 High High
palliative 10 85.60 High High
Disease Link Frequency Relevance Heat
Cancer 55 99.28 Very High Very High Very High
Disease 68 98.72 Very High Very High Very High
INFLAMMATION 48 98.36 Very High Very High Very High
Asthma 69 98.16 Very High Very High Very High
Immunization 2 96.52 Very High Very High Very High
Rheumatoid Arthritis 65 94.84 High High
Rhinitis 10 93.12 High High
Recurrence 6 91.60 High High
Hypersensitivity 31 91.20 High High
Psoriasis 76 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absolute lifetime cost was defined as the incremental cost associated with monoclonal antibody therapy for patients over the course of their disease.
monoclonal Binding (associated) of associated with disease
1) Confidence 0.07 Published 2008 Journal Current Oncology Section Body Doc Link PMC2442764 Disease Relevance 0.84 Pain Relevance 0.09
Tocilizumab is a humanized, anti-human (IL-6) receptor monoclonal antibody of the IgG1 subclass, which prevents IL-6 from binding to its receptor.26 Since it is humanized, it will most likely present lower risk of antibody production compared with murine or chimeric mouse-human antibodies.26
monoclonal antibody Binding (binding) of
2) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 1.05 Pain Relevance 0.21
[Binding of monoclonal antibodies to cerebral cytoplasmic tetrodotoxin-sensitive protein to human lymphocytes].
monoclonal Binding (Binding) of in lymphocytes associated with tetrodotoxin
3) Confidence 0.02 Published 1989 Journal Biull Eksp Biol Med Section Title Doc Link 2478214 Disease Relevance 0 Pain Relevance 0.23
Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2.
antibody-toxin Binding (injected) of associated with cancer
4) Confidence 0.02 Published 2003 Journal Breast Cancer Res. Treat. Section Title Doc Link 14703062 Disease Relevance 0.86 Pain Relevance 0.09
CAT-354 is a high affinity, human monoclonal IgG4 antibody that specifically binds to and neutralises IL-13.
monoclonal Binding (binds) of
5) Confidence 0.01 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 0.79 Pain Relevance 0.30
Cetuximab is a monoclonal antibody that specifically binds to the EGFR, thereby inhibiting downstream signal transduction pathways [29].
monoclonal Binding (binds) of
6) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266352 Disease Relevance 1.12 Pain Relevance 0
Lebrikizumab is a humanized monoclonal antibody that binds to IL-13 and is currently in development for asthma (ClinicalTrials.gov Identifier: NCT00930163).
monoclonal Binding (binds) of associated with asthma
7) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.63 Pain Relevance 0
This enzyme immunoassay is based on monoclonal antibodies bound on the surface of the microwell strips to capture the antigen in stool specimens.
monoclonal Binding (bound) of
8) Confidence 0.01 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC434506 Disease Relevance 0 Pain Relevance 0
Infliximab and adalimumab are monoclonal antibodies that bind to and neutralize the activity of TNF-alpha.
monoclonal Binding (bind) of associated with infliximab and adalimumab
9) Confidence 0.00 Published 2007 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 17786135 Disease Relevance 1.06 Pain Relevance 0.66
Although rabbit polyclonal antiserum blocked human TRPV1 activation, rabbit monoclonal antibodies (identified on the basis of selective binding to Chinese hamster ovary cells expressing human TRPV1) did not block activation by either capsaicin or protons.
monoclonal Binding (binding) of in ovary associated with qutenza
10) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16844842 Disease Relevance 0.10 Pain Relevance 0.75
IDEC-114 is a primatized monoclonal antibody that binds to the high-affinity CD80 receptor found on APCs and certain activated T cells.
monoclonal Binding (binds) of in T cells
11) Confidence 0.00 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.20 Pain Relevance 0.23
Thus, rabbit polyclonal antibodies against rat and human TRPV1 prepore region seem to partially lock or stabilize the channel in the closed state, whereas rabbit anti-human TRPV1 monoclonal antibodies bind to the prepore region but do not lock or stabilize the channel conformation.
monoclonal Binding (bind) of
12) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16844842 Disease Relevance 0.08 Pain Relevance 0.54

General Comments

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