INT24876

Context Info Confidence 0.78 First Reported 1989 Last Reported 2010 Negated 42 Speculated 1 Reported most in Abstract Documents 172 Total Number 175 Disease Relevance 91.02 Pain Relevance 12.39

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34) extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)

Anatomy Link Frequency smooth muscle 9 endothelial cells 8 muscle 6 stem cells 6 bone marrow 6 CD34 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 212 99.60 Snapping jaw 42 99.48 Arthritis 373 99.12 Inflammation 672 98.04 abdominal pain 31 96.08 Bile 28 95.84 ischemia 98 95.24 Chronic pancreatitis 15 94.80 pain pelvic 2 93.72 Dysuria 2 93.20

Disease Link Frequency Relevance Heat Muscular Dystrophy 914 100.00 Paroxysmal Nocturnal Hemoglobinuria 158 100.00 Lymphatic System Cancer 44 100.00 Infection 166 99.98 Gastrointestinal Stromal Tumor 191 99.96 Cancer 1426 99.86 Glomus Tumor 6 99.84 Graft Vs Host Disease 41 99.80 Uterine Fibroids 8 99.80 Herpes Simplex Virus 241 99.78

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, CD34 expression in internal derangement specimens was more intense than in control specimens.

Gene_expression (expression) of CD34 in internal

1) Confidence 0.78 Published 1999 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10432193 Disease Relevance 0.41 Pain Relevance 0.46

In the synovial membrane, CD34 was detected frequently in the walls of many blood capillaries in both the controls and the internal derangement specimens.

Gene_expression (detected) of CD34 in internal

2) Confidence 0.78 Published 1999 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10432193 Disease Relevance 0.43 Pain Relevance 0.43

Thus, we examined the expression of CD34 in 20 human temporomandibular joint (TMJ) samples with internal derangement and in 10 control specimens by an immunohistological technique using paraffin-embedded tissue and specific anti-human CD34 monoclonal antibody.

Gene_expression (expression) of CD34 in TMJ associated with snapping jaw

3) Confidence 0.78 Published 1999 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10432193 Disease Relevance 0.42 Pain Relevance 0.42

Immunohistochemical staining demonstrated an intense expression of CD 31, CD 34, factor VIII related antigen and keratin.

Gene_expression (expression) of CD 34

4) Confidence 0.78 Published 2000 Journal Virchows Arch. Section Abstract Doc Link 10963385 Disease Relevance 0.54 Pain Relevance 0.06

We report that hematopoietic progenitor cells expressing the CD34 antigen (CD34+ cells) transiently circulate in the peripheral blood (PB) of cancer patients treated with 7 g/m2 cyclophosphamide (HD-CTX) with or without recombinant human granulocyte macrophage-colony stimulating factor (rHuGM-CSF).

Gene_expression (expressing) of CD34 in granulocyte associated with cancer

5) Confidence 0.78 Published 1989 Journal Blood Section Abstract Doc Link 2478216 Disease Relevance 0.16 Pain Relevance 0

Immunohistochemistry plays an important role in identifying these rare entities, confirming the endothelial origin of the neoplasm with the expression of at least one of the vascular markers CD31, CD34, or factor VIII-related antigen.

Gene_expression (expression) of CD34 associated with cancer

6) Confidence 0.77 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 20089367 Disease Relevance 1.11 Pain Relevance 0

Immunoperoxidase stains showed characteristic expression of CD34 and vimentin.

Gene_expression (expression) of CD34

7) Confidence 0.76 Published 1996 Journal Am. J. Ophthalmol. Section Body Doc Link 8604743 Disease Relevance 0.08 Pain Relevance 0

Genes that consistently showed differential over- or under expression between CD34+ versus all other cell types were selected as CD34+ -enriched genes.

Gene_expression (expression) of CD34

8) Confidence 0.75 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.09 Pain Relevance 0

CD34 antigen was detected in 74% of cases, BNH9 in 72%, and cytokeratins in 35%.

Gene_expression (detected) of CD34

9) Confidence 0.75 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9630175 Disease Relevance 1.18 Pain Relevance 0.13

Immunohistochemical expression of Factor VIII, CD31 and CD34 antigens was present.

Gene_expression (expression) of CD34

10) Confidence 0.75 Published 2008 Journal Pneumonol Alergol Pol Section Abstract Doc Link 18785134 Disease Relevance 0.99 Pain Relevance 0.12

These tumors are identified by expression of CD117 or CD34 antigen.

Gene_expression (expression) of CD34

11) Confidence 0.75 Published 2008 Journal J Egypt Natl Canc Inst Section Abstract Doc Link 19847285 Disease Relevance 0.94 Pain Relevance 0.10

Coexpression of actin and CD34 in glomus tumors, although unusual, has recently been reported in the literature.

Gene_expression (Coexpression) of CD34 in glomus associated with glomus tumor

12) Confidence 0.74 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987133 Disease Relevance 0.95 Pain Relevance 0.08

About a decade ago, the need for a rapid and reliable marker for the engraftment potential of haematopoietic stem and progenitor cell (HSC) transplants has led to the development of flow cytometric assays to quantitate such cells on the basis of their expression of CD34 [13].

Gene_expression (expression) of CD34 in stem

13) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0 Pain Relevance 0

During the last decade, the ISHAGE (International Society of Hematotherapy and Graft Engineering) method to detect CD34 HSC in haematological studies has been successfully implemented in multicenter trials [23].

Gene_expression (detect) of CD34

14) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0 Pain Relevance 0

Solitary fibrous tumour of the urinary bladder with expression of bcl-2, CD34, and insulin-like growth factor type II.

Gene_expression (expression) of CD34 in urinary bladder associated with cancer

15) Confidence 0.72 Published 2001 Journal Eur. Urol. Section Title Doc Link 11306891 Disease Relevance 0.70 Pain Relevance 0.19

A recent study on staining patterns in vessels indicated that CD34 is expressed on endothelial cells in tumors and fetal tissue, but not during the angiogenic microvascular process in wounded tissue.19 This result suggests that CD34-positive endothelial cells involved in wound healing originate from bone marrow.

Neg (not) Gene_expression (expressed) of CD34 in endothelial cells associated with cancer and wound healing

16) Confidence 0.70 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.59 Pain Relevance 0

The leukocyte antigen, CD34, is known to be expressed on the surfaces of hematopoietic progenitor cells, vascular endothelial cells, and some fibroblasts.12 During the repair process after pterygium excision, round or spindle-shaped, CD34-positive mononuclear cells were observed on the stromal side of the amniotic membrane.

Gene_expression (expressed) of CD34 in fibroblasts associated with conjunctiva disease

17) Confidence 0.70 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.67 Pain Relevance 0

In normal blood, 98% of CD133+ cells also expressed the CD34 antigen, whereas approximately 83–90% of dystrophic blood-derived CD133+ cells also expressed CD34.

Gene_expression (expressed) of CD34 in blood

18) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.35 Pain Relevance 0

In normal blood, 98% of CD133+ cells also expressed the CD34 antigen, whereas approximately 83–90% of dystrophic blood-derived CD133+ cells also expressed CD34.

Gene_expression (expressed) of CD34 in blood

19) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.33 Pain Relevance 0

Cells expressing the CD34 and CD133 markers are associated with hematopoietic activity [33,34].

Gene_expression (expressing) of CD34

20) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0 Pain Relevance 0

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