INT248774

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 8.46
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
ECM 6
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 210 91.08 High High
rheumatoid arthritis 21 82.40 Quite High
Multiple sclerosis 12 72.96 Quite High
cva 1 30.00 Quite Low
cytokine 44 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 48 99.48 Very High Very High Very High
Necrosis 9 98.24 Very High Very High Very High
Apoptosis 57 97.72 Very High Very High Very High
Prostate Cancer 25 96.48 Very High Very High Very High
Atherosclerosis 44 95.96 Very High Very High Very High
INFLAMMATION 216 91.08 High High
Cancer 120 88.96 High High
Infection 21 85.88 High High
Autoimmune Disease 15 85.44 High High
Sepsis 30 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our model atorvastatin increases ECM accumulation what leads to a strengthening of the fibrous cap, while apoptosis was not detectable.
Positive_regulation (increases) of Localization (accumulation) of ECM associated with apoptosis
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.66 Pain Relevance 0.08
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Positive_regulation (upregulated) of Localization (released) of ECM in ECM associated with injury
2) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.91 Pain Relevance 0.28
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Positive_regulation (upregulated) of Localization (released) of ECM in ECM associated with injury
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.93 Pain Relevance 0.28
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Positive_regulation (upregulated) of Localization (released) of extracellular matrix in ECM associated with injury
4) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.94 Pain Relevance 0.28
ADAMTS1 has previously been reported to regulate angiogenesis by cleaving TSP1, which results in the release of TSP1 from ECM and thereby to decreased angiogenesis [9].
Positive_regulation (results) of Localization (release) of ECM
5) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.02 Pain Relevance 0
The gelatin only also promotes ECM secretion.
Positive_regulation (promotes) of Localization (secretion) of ECM
6) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0

General Comments

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