INT248797

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Mns1) nucleus (Mns1)
Mns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
repetitive firing 2 98.56 Very High Very High Very High
Cannabinoid receptor 3 95.60 Very High Very High Very High
Glutamate 22 86.12 High High
Somatostatin 5 84.88 Quite High
depression 52 84.56 Quite High
gABA 8 81.68 Quite High
Action potential 5 81.32 Quite High
tetrodotoxin 18 78.16 Quite High
Opioid 31 77.92 Quite High
medulla 5 77.08 Quite High
Disease Link Frequency Relevance Heat
Depression 46 84.56 Quite High
Nociception 1 40.40 Quite Low
Respiratory Failure 6 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Apnoea 4 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Central Sleep Apnea 2 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obviously some of these receptors, like the receptors for AMPA, kainate, glycine and mGluR1, are also found in MNs [89].
Positive_regulation (found) of MNs
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.21
As seen in our experiments, previous work in neonatal rats in vitro indicates that activation of mACh receptors on XII MNs causes depolarization, facilitates repetitive firing and potentiates XII inspiratory burst output [33], [34].
Positive_regulation (activation) of MNs associated with repetitive firing
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.18 Pain Relevance 0.20
In this group of three MNs the average period increased from 2781±747 ms to 6354±1454 ms in DAMGO (p<0.01) and then recovered partially to 4087±1557 ms following washout of DAMGO (data not shown).


Positive_regulation (increased) of MNs
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.23 Pain Relevance 0.35

General Comments

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