INT24883

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 9.73
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
brain 1
platelets 1
sublingual 1
OPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 16 99.92 Very High Very High Very High
tolerance 14 99.60 Very High Very High Very High
headache 128 99.48 Very High Very High Very High
agonist 2 96.56 Very High Very High Very High
nMDA receptor 2 94.92 High High
Angina 11 89.84 High High
Pain 5 88.40 High High
cva 71 86.24 High High
Clonidine 2 82.40 Quite High
antagonist 4 78.24 Quite High
Disease Link Frequency Relevance Heat
Low Tension Glaucoma 68 100.00 Very High Very High Very High
Hypotension 3 99.98 Very High Very High Very High
Headache 133 99.48 Very High Very High Very High
Ocular Hypertension 68 99.44 Very High Very High Very High
Open-angle Glaucoma 5 98.76 Very High Very High Very High
Cv Unclassified Under Development 33 98.24 Very High Very High Very High
Glaucoma 126 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 96 96.56 Very High Very High Very High
Pressure Volume 2 Under Development 5 95.60 Very High Very High Very High
Retinal Vein Occlusion 77 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A systematic review of the literature revealed 18 published OPA1 positive families segregating a DOA+ phenotype and clinical information was available for 44 affected individuals (mean age = 43.5 years, SD = 17.0 years, Table 1).



Regulation (segregating) of OPA1
1) Confidence 0.45 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.05 Pain Relevance 0
On the other hand, our study included only NTG which is known to be the most prevalent subtype of glaucoma among Koreans.23
Regulation (included) of NTG associated with low tension glaucoma and glaucoma
2) Confidence 0.38 Published 2007 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629887 Disease Relevance 2.30 Pain Relevance 0.31
These results indicate that OPA may be physiologically autoregulated in human subjects with IOPs in the 11-21 mmHg range.
Regulation (autoregulated) of OPA
3) Confidence 0.33 Published 1994 Journal Surv Ophthalmol Section Abstract Doc Link 7940142 Disease Relevance 1.61 Pain Relevance 0.06
We have investigated these two issues by studying the effect of systemically administered NTG (transdermal patches, ointment, and sublingual tablets) on alpha-adrenergic receptor agonist-mediated constriction of human dorsal hand veins.
Regulation (effect) of NTG in sublingual associated with transdermal and agonist
4) Confidence 0.24 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2478766 Disease Relevance 0.09 Pain Relevance 0.53
Lactate-pyruvate ratios and venous NTG concentrations were not significantly affected by NAC.
Neg (not) Regulation (affected) of NTG
5) Confidence 0.23 Published 1988 Journal Circulation Section Abstract Doc Link 3127076 Disease Relevance 0.91 Pain Relevance 0.68
There is a significant between-group difference between NTG and control in the incidence of headache, with an odds ratio of 1.73 (95% CI, 1.01-2.97).
Regulation (control) of NTG
6) Confidence 0.23 Published 2010 Journal Arch Phys Med Rehabil Section Body Doc Link 20684913 Disease Relevance 0 Pain Relevance 0
Exercise in normal volunteers increased calculated ocular perfusion pressure by 22.5%, lowered IOP by 32%, but showed no significant change in OPA.
Neg (no) Regulation (change) of OPA associated with ocular hypertension
7) Confidence 0.20 Published 1994 Journal Surv Ophthalmol Section Abstract Doc Link 7940142 Disease Relevance 1.86 Pain Relevance 0.08
Despite development of tolerance to the hypotensive effect of NTG, arterial and venous thiol levels are similar in nitrate tolerant and non-tolerant animals, suggesting that depletion of vascular thiol compounds may not be the cause of nitrate tolerance in vivo.
Regulation (effect) of NTG associated with hypotension and tolerance
8) Confidence 0.19 Published 1995 Journal Dan Med Bull Section Abstract Doc Link 8747803 Disease Relevance 0.32 Pain Relevance 0.20
The efficacy of NTG was evaluated by analyzing walking time to ischaemia (WTI) during exercise tests performed 5 minutes after NTG or SLP administration, and the efficacy of ISDN 2 h and 6 h after oral ingestion.
Regulation (efficacy) of NTG associated with cv unclassified under development
9) Confidence 0.17 Published 2004 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 15115903 Disease Relevance 0.68 Pain Relevance 0.20
The differences between NTG and controls were reversed during elevated CO2 breathing, suggesting the presence of a reversible vasospasm in the NTG cohort (Harris et al 1994).
Regulation (controls) of NTG associated with low tension glaucoma and increased venous pressure under development
10) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.78 Pain Relevance 0.13
The VAS can detect subtle changes in subjective complaints (i.e. headache), has documented reliability, and has been used in several studies designed to study the effects of NTG ointment on headache in healthy women [56,57].


Regulation (effects) of NTG associated with headache
11) Confidence 0.08 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.93 Pain Relevance 0.93
An alternative design would be a single study on the effects of three treatments (placebo, NTG, ISMO) on BMD, bone turnover markers, and pQCT.
Regulation (effects) of NTG
12) Confidence 0.05 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0 Pain Relevance 0
The cGMP-elevating efficacy of NTG and SNP was diminished in platelets from patients in comparison with those from normals (P<0.001).
Regulation (efficacy) of NTG in platelets
13) Confidence 0.03 Published 1999 Journal Circulation Section Body Doc Link 10402441 Disease Relevance 0 Pain Relevance 0
Our data suggest that the stimulating effect of NTG, and thus of NO, on the expression of nNOS might be modulated by increasing the KYNA level in the brain, probably through the NMDA receptors.
Regulation (effect) of NTG in brain associated with nmda receptor
14) Confidence 0.02 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.20 Pain Relevance 0.32

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