INT24884

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.35
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
dorsal horn 4
joints 2
knee joints 2
neurons 2
sensory nerves 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 204 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
Dorsal horn 9 100.00 Very High Very High Very High
Dorsal horn neuron 1 100.00 Very High Very High Very High
narcan 5 99.98 Very High Very High Very High
Pain 25 99.82 Very High Very High Very High
qutenza 14 99.52 Very High Very High Very High
Inflammation 72 99.50 Very High Very High Very High
Kinase C 21 99.28 Very High Very High Very High
Thermal hyperalgesia 4 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 71 99.50 Very High Very High Very High
Hyperalgesia 16 97.24 Very High Very High Very High
Nociception 16 97.08 Very High Very High Very High
Arthritis 60 94.76 High High
Ganglion Cysts 273 89.00 High High
Pain 21 72.52 Quite High
Stress 1 69.60 Quite High
Neuropathic Pain 1 33.88 Quite Low
Inflammatory Pain 7 5.00 Very Low Very Low Very Low
Arthralgia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with LY306,740 (but not LY307,679) completely blocked the formalin-induced increase in dorsal horn NK-1R mRNA levels and significantly reduced formalin-induced behavioral activity.
Negative_regulation (blocked) of Positive_regulation (increase) of NK-1R mRNA in dorsal horn associated with dorsal horn
1) Confidence 0.43 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.31
Excitation of pancreatic sensory nerves using capsaicin (in the absence of SP) inhibited both amylase and pancreatic juice flow via activation of the NK1 receptor.
Negative_regulation (inhibited) of Positive_regulation (activation) of NK1 receptor in sensory nerves associated with qutenza and substance p
2) Confidence 0.40 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10444445 Disease Relevance 0 Pain Relevance 0.60
Under inflammatory conditions, all noxious stimulus-induced NK-1 receptor internalization in deep dorsal horn neurons was blocked by GR 205171, suggesting that it is entirely NKA-mediated.
Negative_regulation (blocked) of Positive_regulation (stimulus-induced) of NK-1 receptor in neurons associated with inflammation and dorsal horn neuron
3) Confidence 0.40 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.17 Pain Relevance 0.79
Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites.
Negative_regulation (prevented) of Positive_regulation (upregulation) of NK-1 receptor associated with qutenza and substance p
4) Confidence 0.39 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12169105 Disease Relevance 0.27 Pain Relevance 1.93
Naloxone blocks the formalin-induced increase of substance P in the dorsal horn.
Negative_regulation (blocks) of Positive_regulation (increase) of substance P in dorsal horn associated with dorsal horn, narcan and substance p
5) Confidence 0.38 Published 1989 Journal Pain Section Title Doc Link 2478946 Disease Relevance 0.27 Pain Relevance 1.37
can completely block both the neurokinin-1 receptor agonist-induced TRPV1 (transient receptor potential vanilloid subtype 1) potentiation and heat hyperalgesia [38].
Negative_regulation (block) of Positive_regulation (induced) of neurokinin-1 associated with hyperalgesia and agonist
6) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.48 Pain Relevance 1.18
Although FLS cells from both acutely and chronically inflamed joints produced elevated levels of PGE2, only the upregulation of NK1 receptor-like IR by FLS cells from acutely inflamed joints was prevented by indomethacin, suggesting that prostaglandins and/or other COX products are relevant mediators for receptor regulation in acute arthritis but not in chronic arthritis.
Negative_regulation (prevented) of Positive_regulation (upregulation) of NK1 receptor in joints associated with arthritis
7) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.49 Pain Relevance 0.31
However, indomethacin did not prevent upregulation of NK1 receptor-like IR in co-cultures with FLS cells from chronically inflamed knee joints, consistent with the finding that the supernatant from FLS cells from chronically inflamed knee joints did not induce upregulation of NK1 receptor-like IR.
Negative_regulation (prevent) of Positive_regulation (upregulation) of NK1 receptor in knee joints
8) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.34 Pain Relevance 0.17

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