INT24890

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Context Info
Confidence 0.73
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.22
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
epidermis 1
internal 1
external 1
tubules 1
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
substance P 14 99.24 Very High Very High Very High
Hippocampus 4 94.16 High High
tetrodotoxin 2 83.28 Quite High
cva 3 81.04 Quite High
long-term potentiation 1 36.24 Quite Low
imagery 3 27.88 Quite Low
Neuropeptide 1 25.00 Low Low
headache 1 6.88 Low Low
Disease Link Frequency Relevance Heat
Cancer 22 97.80 Very High Very High Very High
Metastasis 9 90.88 High High
Syndrome 2 87.84 High High
Vipoma 1 87.48 High High
Hemorrhage 3 81.04 Quite High
Necrosis 8 79.84 Quite High
Disease 7 79.76 Quite High
Ganglioneuroma 1 79.36 Quite High
Striatonigral Degeneration 6 78.40 Quite High
Ganglioneuroblastoma 1 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pancreatic and jejunal tumors showed all structural and secretory patterns of epithelial endocrine tumors, including expression of cytokeratin, neuroendocrine markers like neuron-specific enolase, chromogranins and synaptophysin, peptides like VIP, PHM, GRH, PP, insulin, neurotensin, glucagon, somatostatin and enkephalin, secretory granules, small clear vesicles, peculiar osmiophilic bodies, and occasional formation of tubules or microacini with specialized luminal surfaces.
Localization (secretory) of synaptophysin in tubules associated with cancer, somatostatin and enkephalin
1) Confidence 0.73 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2839087 Disease Relevance 0.94 Pain Relevance 0.26
EP 1, EP 2 and EP 4 were mainly colocalized with synaptophysin, suggesting the presence of EP 1, EP 2, and EP 4 in presynaptic terminals.
Localization (colocalized) of synaptophysin
2) Confidence 0.73 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16041798 Disease Relevance 0 Pain Relevance 0.22
Formalin-fixed and paraffin-embedded pancreatic tissue was used as a positive control for synaptophysin, chromogranin, and neuron-specific enolase (NSE); hepatic tissue for alpha-fetoprotein (AFP) and Hep-Par1; and epidermis for cytokeratin.
Localization (tissue) of synaptophysin in epidermis
3) Confidence 0.73 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950516 Disease Relevance 0.51 Pain Relevance 0.07
In normal control case, MEnk and SP-like immunoreactivities were densely localized in the external and internal pallidal segments, respectively, whereas calcineurin and synaptophysin were distributed throughout the globus pallidus.
Localization (localized) of synaptophysin in external associated with enkephalin and substance p
4) Confidence 0.68 Published 1989 Journal Acta Neuropathol. Section Abstract Doc Link 2479214 Disease Relevance 0.39 Pain Relevance 0.85
In normal control case, MEnk and SP-like immunoreactivities were densely localized in the external and internal pallidal segments, respectively, whereas calcineurin and synaptophysin were distributed throughout the globus pallidus.
Localization (localized) of synaptophysin in internal associated with enkephalin and substance p
5) Confidence 0.23 Published 1989 Journal Acta Neuropathol. Section Abstract Doc Link 2479214 Disease Relevance 0.39 Pain Relevance 0.85

General Comments

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