INT24891

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2011
Negated 9
Speculated 0
Reported most in Abstract
Documents 55
Total Number 55
Disease Relevance 45.76
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
neuron 10
ganglion cells 5
neuronal 3
dendrites 1
hepatocyte 1
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
Serotonin 17 100.00 Very High Very High Very High
Somatostatin 14 99.80 Very High Very High Very High
Glutamate 46 99.44 Very High Very High Very High
substance P 14 97.32 Very High Very High Very High
Calcitonin gene-related peptide 2 96.00 Very High Very High Very High
vincristine 1 95.52 Very High Very High Very High
cva 14 95.24 Very High Very High Very High
Inflammation 45 95.20 Very High Very High Very High
Bile 8 94.36 High High
Disease Link Frequency Relevance Heat
Carcinoid 65 99.96 Very High Very High Very High
Cancer 536 99.86 Very High Very High Very High
Small Cell Lung Cancer 8 99.84 Very High Very High Very High
Ganglion Cysts 150 99.76 Very High Very High Very High
Oligodendroglioma 228 99.28 Very High Very High Very High
Anaplastic Astrocytoma 1 99.16 Very High Very High Very High
Carcinoma 71 98.64 Very High Very High Very High
Adenocarcinoma 20 98.24 Very High Very High Very High
Necrosis 74 98.08 Very High Very High Very High
Neuroendocrine Cancer 97 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.
Gene_expression (expressed) of synaptophysin
1) Confidence 0.75 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.77 Pain Relevance 0.07
Keratin, chromogranin, and synaptophysin were positive in all tumors.
Gene_expression (positive) of synaptophysin associated with cancer
2) Confidence 0.75 Published 2003 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12931547 Disease Relevance 1.18 Pain Relevance 0.07
Immune histology demonstrated serotonin-synaptophysin-chromogranin-producing carcinoids.
Gene_expression (producing) of synaptophysin associated with carcinoid and serotonin
3) Confidence 0.75 Published 2009 Journal Zentralbl Chir Section Abstract Doc Link 19757351 Disease Relevance 1.44 Pain Relevance 0.13
Decreases in the expression of synaptophysin (SYN), an integral protein in presynaptic terminals, and microtubule-associated protein 2 (MAP2), a marker for neuronal cell bodies and dendrites, reflect neurodegeneration severity and have been found to correlate to the degree of neurocognitive impairment in persons with HIV [26].
Gene_expression (expression) of synaptophysin in dendrites associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.40 Pain Relevance 0
Synaptophysin (SYN) is a membrane-bound glycoprotein of the small synaptic vesicles, consistently expressed in all pre-synaptic nerve endings of the CNS [63].
Gene_expression (expressed) of Synaptophysin in nerve
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.41 Pain Relevance 0.19
These comprised a patterned biphasic mixture of sheets of synaptophysin-expressing small round cells and pseudorosettes of GFAP-positive rudimentary astrocytes along vascular cores.
Gene_expression (expressing) of synaptophysin in astrocytes
6) Confidence 0.75 Published 2006 Journal Pathol. Res. Pract. Section Abstract Doc Link 16413693 Disease Relevance 1.15 Pain Relevance 0.12
Immunohistochemical staining revealed diffuse expression of synaptophysin and neurofilament protein, and focal expression of glial fibrillary acidic protein, S-100 protein, desmin, and myoglobin.
Gene_expression (expression) of synaptophysin
7) Confidence 0.75 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.71 Pain Relevance 0.09
Immunohistochemistry revealed expression of synaptophysin by many of the dysplastic ganglion cells, with some co-expressing neurofilament protein and occasionally glial fibrillary acidic protein (GFAP).
Gene_expression (expression) of synaptophysin in ganglion cells associated with ganglion cysts
8) Confidence 0.75 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18363942 Disease Relevance 1.13 Pain Relevance 0.11
Population of cells expressing neuron-specific enolase, synaptophysin, and chromogranin A, which were stained by paraldehyde-fuchsin, was demonstrated in subodontoblastic layer of the dental pulp.
Gene_expression (expressing) of synaptophysin in dental pulp
9) Confidence 0.75 Published 2007 Journal Morfologiia Section Abstract Doc Link 17722571 Disease Relevance 0 Pain Relevance 0.08
Microscopically, the epithelial areas were composed of well-defined nests of large cells with peripheral palisading expressing low-molecular-weight keratin, synaptophysin, chromogranin, and neuron-specific enolase.
Gene_expression (expressing) of synaptophysin in neuron
10) Confidence 0.75 Published 2001 Journal Ann Diagn Pathol Section Abstract Doc Link 11510007 Disease Relevance 0.95 Pain Relevance 0.09
All of the neoplasms expressed chromogranin and two expressed synaptophysin.
Gene_expression (expressed) of synaptophysin associated with cancer
11) Confidence 0.75 Published 2000 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11075851 Disease Relevance 1.36 Pain Relevance 0.37
Biopsy samples from eutopic endometrium were used for immunohistochemical staining to detect synaptophysin (SYN) and neuron-specific enolase (NSE) expression in women with and without endometriosis.
Gene_expression (expression) of synaptophysin in neuron
12) Confidence 0.75 Published 2010 Journal Hum. Reprod. Section Body Doc Link 19910323 Disease Relevance 0 Pain Relevance 0
Immunohistochemical study revealed that the tumor cells expressed positivity against CD99 (MIC2), neuron-specific enolase, synaptophysin and vimentin.
Gene_expression (expressed) of synaptophysin in neuron associated with cancer
13) Confidence 0.75 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849329 Disease Relevance 0.42 Pain Relevance 0.08
Immunohistochemical staining of tumor cells showed positive expressions of prolactin, synaptophysin and chromogranin A in the cytoplasm of the tumor cells.
Gene_expression (expressions) of synaptophysin associated with cancer
14) Confidence 0.75 Published 2010 Journal Neuropathology Section Abstract Doc Link 19737358 Disease Relevance 1.11 Pain Relevance 0.11
The tumor cells were negative for chromogranin but expressed synaptophysin and CD56, consistent with the immunoprofile of a neuroendocrine tumor (NET).
Gene_expression (expressed) of synaptophysin associated with neuroendocrine cancer and cancer
15) Confidence 0.75 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2542373 Disease Relevance 0.95 Pain Relevance 0.03
The latter two components variably express pan-NE markers including NSE, chromogranin (s) and, notably, synaptophysin.
Gene_expression (express) of synaptophysin
16) Confidence 0.75 Published 1988 Journal Pathol. Res. Pract. Section Abstract Doc Link 3290868 Disease Relevance 0.63 Pain Relevance 0.23
Examination of the biopsy by immunohistochemistry and ultrastructural study revealed it to be neuroendocrine in nature, expressing synaptophysin, chromogranin and cytokeratin and containing dense core cytoplasmic granules.
Gene_expression (expressing) of synaptophysin
17) Confidence 0.74 Published 2009 Journal Dig Endosc Section Abstract Doc Link 19691767 Disease Relevance 0.50 Pain Relevance 0.17
Neoplastic cells were strongly immunoreactive for CD99 and vimentin and were negative for chromogranin, synaptophysin, CD31, CD34, calcitonin, desmin, low-molecular weight cytokeratins, wide-spectrum cytokeratins, leukocyte common antigen, S-100 protein, and thyroid transcription factor-1.
Neg (negative) Gene_expression (negative) of synaptophysin in thyroid
18) Confidence 0.65 Published 2008 Journal Tumori Section Abstract Doc Link 19267114 Disease Relevance 1.35 Pain Relevance 0.16
All tumor cells were negative for Ker 20, chromogranin and synaptophysin.
Neg (negative) Gene_expression (negative) of synaptophysin associated with cancer
19) Confidence 0.65 Published 2010 Journal Cases J Section Body Doc Link PMC2825199 Disease Relevance 1.52 Pain Relevance 0.06
Immunohistochemically, the tumor cells were positive for synaptophysin, chromogranin A, and CD56.
Gene_expression (positive) of synaptophysin associated with cancer
20) Confidence 0.65 Published 2009 Journal J Chin Med Assoc Section Abstract Doc Link 19948438 Disease Relevance 1.18 Pain Relevance 0.07

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