INT248923

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 1.23
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 12
lymph nodes 1
anterior chamber 1
Klrd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 176 99.92 Very High Very High Very High
tolerance 32 37.48 Quite Low
anesthesia 16 5.00 Very Low Very Low Very Low
isoflurane 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 112 99.64 Very High Very High Very High
Hypersensitivity 80 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study showed that expression of CD94 was up-regulated on CD8+T cells during ACAID.
Gene_expression (expression) of CD94 in T cells
1) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
We first examined the expression of CD94 and NKG2A on splenic CD8+T cells.
Spec (examined) Gene_expression (expression) of CD94 in T cells
2) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.08 Pain Relevance 0.07
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Gene_expression (expression) of CD94 in T cells associated with immunization
3) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.15 Pain Relevance 0.08
Della Chiesa and coworkers[16] found that a NK cell subset expressing CD94-NKG2A in lymph nodes was capable of killing immature DC and mature DC to prevent the overactivation of DCs.
Gene_expression (expressing) of CD94 in lymph nodes
4) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
Given the important role of cytokines in CD94-NKG2A expression [19-23], this upregulated receptor may be due to the promotion of certain cytokines from the splenic immunomodulatory microenvironment during the induction of ACAID.
Gene_expression (expression) of CD94 associated with cytokine
5) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.17 Pain Relevance 0.10
Interestingly, we also found an increased expression of CD94-NKG2A in mice following conventional immunization.
Gene_expression (expression) of CD94 associated with immunization
6) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.19 Pain Relevance 0.09
These data suggest that the induced expression of CD94 molecule is associated with the inhibitory effect of CD8+T cells following OVA inoculation into the anterior chamber.
Gene_expression (expression) of CD94 in anterior chamber
7) Confidence 0.56 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.09
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Gene_expression (expression) of CD94 in T cells associated with immunization
8) Confidence 0.49 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.15 Pain Relevance 0.08
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Gene_expression (cocultured) of CD94 in T cells
9) Confidence 0.49 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
As both intracameral inoculation and conventional immunization could upregulate CD94-NKG2A expression, we examined the inhibitory effect of CD8+CD94+T cells from ACAID mice and immunized mice on the proliferation of splenic MNC in vitro.
Gene_expression (expression) of CD94 in T cells associated with immunization
10) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.10 Pain Relevance 0
As shown in Figure 2, the frequencies of CD94 and NKG2A expression on CD8+T cells from spleens were significantly higher in ACAID mice(8.68%, 2.92%) compared with immunized mice(6.0%, 2.2%), OVA-AC-injected mice(5.84%, 2.25%), PBS-AC-injected mice(2.65%, 1.27%) and naïve mice(2.56%, 1.21%).
Gene_expression (expression) of CD94 in T cells
11) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
RT-PCR and flow cytometry were used to investigate the expression of CD94 and NKG2A on CD8+T cells at the mRNA and protein level during ACAID.
Spec (investigate) Gene_expression (expression) of CD94 in T cells
12) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
As shown in Figure 1, mRNA of CD94 and NKG2A was detectable on CD8+T cells in all groups, but it was significantly higher in ACAID mice as compared to immunized mice, OVA-AC-injected mice, PBS-AC-injected mice and naïve mice.
Gene_expression (detectable) of CD94 in T cells
13) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.06 Pain Relevance 0
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Gene_expression (Expression) of CD94 in T cells
14) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3, the expression of intracellular granzyme B, perforin and Foxp3 in fresh CD8+CD94+T cells was minimal(~0.04%, ~0.01% and ~0.01%) in ACAID mice, immunized mice, PBS-AC-injected mice and naïve mice.
Gene_expression (expression) of CD94 in T cells
15) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Gene_expression (cocultured) of CD94 in T cells
16) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05

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